| Literature DB >> 16933266 |
Abstract
Thrombopoietin (TPO) regulates megakaryopoiesis and the generation of platelets. Recombinant TPO has been investigated in clinical studies for use in thrombocytopenia with limited success. A new peptibody, AMG 531, has been shown to increase platelet counts in preclinical and Phase 1 and Phase 2 studies and to be generally safe and tolerable in those studies. Copyright (c) 2006 Wiley-Liss, Inc.Entities:
Mesh：
Substances：
Year: 2006 PMID： 16933266 DOI： 10.1002/pbc.20972
Source DB: PubMed Journal: Pediatr Blood Cancer ISSN： 1545-5009 Impact factor: 3.167