OBJECTIVE: To test the hypothesis that bone mineral density (BMD), a possible surrogate of lifetime exposure to hormone/growth factor/vitamin D/calcium exposure, is higher in prostate cancer cases than controls. METHODS: Hip BMD was measured by dual X-ray absorptiometry in 222 Afro-Caribbean screening-detected prostate cancer cases and 1,503 screened non-cases, aged 45-79, in the population-based Tobago Prostate Survey. Because possible skeletal metastases may modulate BMD, men with prostate specific antigen >20 ng/ml or highly undifferentiated tumors (Gleason score > or = 8) were excluded. Mean BMD, adjusted for age and body mass index, was compared in cases and non-cases by analysis of variance. Risk across age group-specific BMD quartiles was compared using logistic regression. RESULTS: Overall, adjusted mean hip BMD was higher in cases (1.157 g/cm2) than non-cases (1.134 g/cm2) (p = 0.02). In men aged 60-79, prostate cancer risk was two-fold higher (OR, 2.12; 95% CI: 1.21-3.71) in the highest BMD quartile compared to the lowest. There was no association in younger men (interaction, p = 0.055). CONCLUSIONS: High bone density is associated with prostate cancer among older men, consistent with an etiological role for lifetime exposure to factors which modulate bone density. However, other etiologies may dominate prostate cancer risk among younger men.
OBJECTIVE: To test the hypothesis that bone mineral density (BMD), a possible surrogate of lifetime exposure to hormone/growth factor/vitamin D/calcium exposure, is higher in prostate cancer cases than controls. METHODS: Hip BMD was measured by dual X-ray absorptiometry in 222 Afro-Caribbean screening-detected prostate cancer cases and 1,503 screened non-cases, aged 45-79, in the population-based Tobago Prostate Survey. Because possible skeletal metastases may modulate BMD, men with prostate specific antigen >20 ng/ml or highly undifferentiated tumors (Gleason score > or = 8) were excluded. Mean BMD, adjusted for age and body mass index, was compared in cases and non-cases by analysis of variance. Risk across age group-specific BMD quartiles was compared using logistic regression. RESULTS: Overall, adjusted mean hip BMD was higher in cases (1.157 g/cm2) than non-cases (1.134 g/cm2) (p = 0.02). In men aged 60-79, prostate cancer risk was two-fold higher (OR, 2.12; 95% CI: 1.21-3.71) in the highest BMD quartile compared to the lowest. There was no association in younger men (interaction, p = 0.055). CONCLUSIONS: High bone density is associated with prostate cancer among older men, consistent with an etiological role for lifetime exposure to factors which modulate bone density. However, other etiologies may dominate prostate cancer risk among younger men.
Authors: Stacy Loeb; H Ballentine Carter; Edward M Schaeffer; Shari M Ling; Anna Kettermann; Luigi Ferrucci; E Jeffrey Metter Journal: BJU Int Date: 2010-01-06 Impact factor: 5.588
Authors: Ghada N Farhat; Emanuela Taioli; Jane A Cauley; Joseph M Zmuda; Eric Orwoll; Douglas C Bauer; Timothy J Wilt; Andrew R Hoffman; Tomasz M Beer; James M Shikany; Nicholas Daniels; June Chan; Howard A Fink; Elizabeth Barrett-Connor; J Kellogg Parsons; Clareann H Bunker Journal: Cancer Epidemiol Biomarkers Prev Date: 2009-01 Impact factor: 4.254
Authors: Laura M Yerges; Yingze Zhang; Jane A Cauley; Candace M Kammerer; Cara S Nestlerode; Victor W Wheeler; Alan L Patrick; Clareann H Bunker; Susan P Moffett; Robert E Ferrell; Joseph M Zmuda Journal: J Bone Miner Res Date: 2009-01 Impact factor: 6.741
Authors: Camille C Ragin; Emanuela Taioli; Norma McFarlane-Anderson; Gordon Avery; Franklyn Bennett; Adelia Bovell-Benjamin; Angela Brown Thompson; Agatha Carrington; Lydia Campbell-Everett; Jacqueline Ford; Anselm Hennis; Maria Jackson; Sandra Lake; M Cristina Leske; Carol Magai; Barbara Nemesure; Alfred Neugut; Folakemi Odedina; Michael Okobia; Alan Patrick; Wallis Best Plummer; R Renee Reams; Robin Roberts; Sharaneen Scott-Hastings; Sangita Sharma; Victor Wheeler; Suh-Yuh Wu; Clareann Bunker Journal: Infect Agent Cancer Date: 2007-09-24 Impact factor: 2.965