Literature DB >> 16931433

Total synthesis and biological evaluation of (+)- and (-)-Butyl ester of rosmarinic acid.

L-J Huang1, C-H Li, Z-M Lu, Z-B Ma, D-Q Yu.   

Abstract

An efficient method for the synthesis of the natural product (+)-(R)-butyl ester of rosmarinic acid (+)-(R)-1 and its enantiomer ( - )-(S)-1 has been developed by chemical resolution of its phenyl lactic acid precursors 4 with ( - )-menthol. Their antioxidative and anti-tumor activities were evaluated.

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Year:  2006        PMID: 16931433     DOI: 10.1080/10286020500176229

Source DB:  PubMed          Journal:  J Asian Nat Prod Res        ISSN: 1028-6020            Impact factor:   1.569


  3 in total

1.  Construction of a chimeric biosynthetic pathway for the de novo biosynthesis of rosmarinic acid in Escherichia coli.

Authors:  Sarah E Bloch; Claudia Schmidt-Dannert
Journal:  Chembiochem       Date:  2014-09-09       Impact factor: 3.164

Review 2.  Bioinspired syntheses of dimeric hydroxycinnamic acids (lignans) and hybrids, using phenol oxidative coupling as key reaction, and medicinal significance thereof.

Authors:  George E Magoulas; Dionissios Papaioannou
Journal:  Molecules       Date:  2014-11-28       Impact factor: 4.411

3.  Short Chain (≤C4) Esterification Increases Bioavailability of Rosmarinic Acid and Its Potency to Inhibit Vascular Smooth Muscle Cell Proliferation.

Authors:  Tina Blažević; Gottfried Reznicek; Limin Ding; Gangqiang Yang; Patricia Haiss; Elke H Heiss; Verena M Dirsch; Rongxia Liu
Journal:  Front Pharmacol       Date:  2021-01-21       Impact factor: 5.810

  3 in total

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