| Literature DB >> 16931037 |
Robert T Woodland1, Madelyn R Schmidt, Craig B Thompson.
Abstract
Naïve peripheral B cells survive in vivo because of active stimulation by the TNF superfamily ligand B lymphocyte stimulator (BLyS/BAFF). Although the survival promoting properties of BLyS are well known, the signal pathways and molecular effectors that characterize this stimulation are still being elucidated. In this communication, we discuss the signal cascades that effect BLyS dependent survival and the regulation of BLyS induced signaling. We also examine the role of BLyS as a growth factor and propose that BLyS induced metabolic enhancement optimizes the B cell response to BCR and TLR-dependent signaling.Entities:
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Year: 2006 PMID： 16931037 DOI： 10.1016/j.smim.2006.06.001
Source DB: PubMed Journal: Semin Immunol ISSN： 1044-5323 Impact factor: 11.130