| Literature DB >> 16931028 |
Atsushi Naganawa1, Toshiaki Matsui, Masaki Ima, Koji Yoshida, Hiroshi Tsuruta, Shingo Yamamoto, Hiroshi Yamamoto, Hiroki Okada, Takayuki Maruyama, Hisao Nakai, Kigen Kondo, Masaaki Toda.
Abstract
A series of 4-[(2-{isobutyl[(5-methyl-2-furyl)sulfonyl]amino}phenoxy)methyl]benzoic acids and 4-({2-[isobutyl(1,3-thiazol-2-ylsulfonyl)amino]phenoxy}methyl)benzoic acids were synthesized and evaluated for their EP receptor affinities and EP1 receptor antagonist activities. Further structural optimization was carried out to reduce inhibitory activity against hepatic cytochrome P450 isozymes, which could represent a harmful potential drug interaction. Selected compounds were also evaluated for their binding affinities to hTP, hDP, mFP, and hIP, and for their hEP1 receptor antagonist activities. The results of structure-activity relationship studies are also presented.Entities:
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Year: 2006 PMID： 16931028 DOI： 10.1016/j.bmc.2006.08.001
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641