PURPOSE: To assess the possible cognitive alterations in epilepsy patients compared with controls over 5 years, and to investigate the clinical variables mainly implied in mental impairment. METHODS: In our longitudinal single-center study, 50 patients with temporal lobe epilepsy (TLE) and 50 controls were administered the same battery of comprehensive neuropsychological tests at baseline and after 5 years. RESULTS: TLE patients showed a significant impairment in attention and psychomotor speed compared with controls after 5 years, while the other cognitive domains did not exhibit any important changes. This worsening was mainly related to the duration of epilepsy, the age at onset, a history of tonic-clonic seizures and a low educational level. CONCLUSIONS: We believe that tapping the attention and psychomotor speed decline in TLE patients should be considered relevant for future research, in order to achieve a deeper understanding of the cognitive dimensions of this field.
PURPOSE: To assess the possible cognitive alterations in epilepsypatients compared with controls over 5 years, and to investigate the clinical variables mainly implied in mental impairment. METHODS: In our longitudinal single-center study, 50 patients with temporal lobe epilepsy (TLE) and 50 controls were administered the same battery of comprehensive neuropsychological tests at baseline and after 5 years. RESULTS:TLEpatients showed a significant impairment in attention and psychomotor speed compared with controls after 5 years, while the other cognitive domains did not exhibit any important changes. This worsening was mainly related to the duration of epilepsy, the age at onset, a history of tonic-clonic seizures and a low educational level. CONCLUSIONS: We believe that tapping the attention and psychomotor speed decline in TLEpatients should be considered relevant for future research, in order to achieve a deeper understanding of the cognitive dimensions of this field.
Authors: E S Schwartz; D J Dlugos; P B Storm; J Dell; R Magee; T P Flynn; D M Zarnow; R A Zimmerman; T P L Roberts Journal: AJNR Am J Neuroradiol Date: 2008-02-13 Impact factor: 3.825
Authors: Kevin Dabbs; Tara Becker; Jana Jones; Paul Rutecki; Michael Seidenberg; Bruce Hermann Journal: Epilepsia Date: 2012-04-03 Impact factor: 5.864
Authors: Connie Sung; Jana E Jones; Daren C Jackson; Yui Chung Chan; Fong Chan; Michael Seidenberg; Bruce P Hermann Journal: Epilepsy Res Date: 2012-09-16 Impact factor: 3.045
Authors: Margaret P Jacobs; Gabrielle G Leblanc; Amy Brooks-Kayal; Frances E Jensen; Dan H Lowenstein; Jeffrey L Noebels; Dennis D Spencer; John W Swann Journal: Epilepsy Behav Date: 2009-03 Impact factor: 2.937
Authors: Alix Warburton; Fabio Miyajima; Kanvel Shazadi; Joanne Crossley; Michael R Johnson; Anthony G Marson; Gus A Baker; John P Quinn; Graeme J Sills Journal: Epilepsy Behav Date: 2015-12-17 Impact factor: 2.937
Authors: Camille Garcia-Ramos; Kevin Dabbs; Elizabeth Meyerand; Vivek Prabhakaran; David Hsu; Jana Jones; Michael Seidenberg; Bruce Hermann Journal: Neuroimage Clin Date: 2018-04-20 Impact factor: 4.881