Literature DB >> 1693092

Alternate methods of representing single-channel data.

S V Ramanan1, P R Brink.   

Abstract

Clustering of dwell times in data from single-channel recordings, which is in excess of the value predicted from the probability density function (pdf) alone, provides restrictions on modeling schemes. Two methods, (a) the probability density function of the running median for groups of any size of sequential dwell times, and (b) the distribution of cumulative probabilities associated with dwell times separated by any lag, or the second cumulative probability distribution, are proposed as alternative representations of single-channel data; these methods are suitable for the detection of such clusters or modes. Simulation of three models with and without modes is done to test the efficacy of these methods. It is found that they often yield a better estimate of moding parameters than the methods of running mean pdf and autocorrelation.

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Year:  1990        PMID: 1693092      PMCID: PMC1280790          DOI: 10.1016/S0006-3495(90)82609-6

Source DB:  PubMed          Journal:  Biophys J        ISSN: 0006-3495            Impact factor:   4.033


  9 in total

1.  A note on correlations in single ion channel records.

Authors:  D Colquhoun; A G Hawkes
Journal:  Proc R Soc Lond B Biol Sci       Date:  1987-02-23

2.  Kinetic analysis of channel gating. Application to the cholinergic receptor channel and the chloride channel from Torpedo californica.

Authors:  P Labarca; J A Rice; D R Fredkin; M Montal
Journal:  Biophys J       Date:  1985-04       Impact factor: 4.033

3.  Single-channel autocorrelation functions: the effects of time interval omission.

Authors:  F G Ball; M S Sansom
Journal:  Biophys J       Date:  1988-05       Impact factor: 4.033

4.  Rate-amplitude correlation from single-channel records. A hidden structure in ion channel gating kinetics?

Authors:  G L Millhauser; E E Salpeter; R E Oswald
Journal:  Biophys J       Date:  1988-12       Impact factor: 4.033

5.  Data transformations for improved display and fitting of single-channel dwell time histograms.

Authors:  F J Sigworth; S M Sine
Journal:  Biophys J       Date:  1987-12       Impact factor: 4.033

6.  Kinetic states and modes of single large-conductance calcium-activated potassium channels in cultured rat skeletal muscle.

Authors:  O B McManus; K L Magleby
Journal:  J Physiol       Date:  1988-08       Impact factor: 5.182

7.  On the stochastic properties of single ion channels.

Authors:  D Colquhoun; A G Hawkes
Journal:  Proc R Soc Lond B Biol Sci       Date:  1981-03-06

8.  Calcium dependence of open and shut interval distributions from calcium-activated potassium channels in cultured rat muscle.

Authors:  K L Magleby; B S Pallotta
Journal:  J Physiol       Date:  1983-11       Impact factor: 5.182

9.  Relationship between membrane excitability and single channel open-close kinetics.

Authors:  J R Clay; L J DeFelice
Journal:  Biophys J       Date:  1983-05       Impact factor: 4.033

  9 in total
  1 in total

Review 1.  Calcium-activated potassium channels: regulation by calcium.

Authors:  O B McManus
Journal:  J Bioenerg Biomembr       Date:  1991-08       Impact factor: 2.945

  1 in total

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