Literature DB >> 16930079

Exploration of the Mitsunobu reaction with Tosyl- and Boc-hydrazones as nucleophilic agents.

John M Keith1, Leslie Gomez.   

Abstract

Tosyl- and Boc-hydrazones were found to be effective nucleophiles in the Mitsunobu reaction. Tosyl hydrazones reacted cleanly with primary and secondary alcohols when co-administered to a cooled DBAD/PPh3 or DEAD/PPh3 complex. Boc-hydrazones required electron-withdrawing substituents to participate in the reaction.

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Year:  2006        PMID： 16930079     DOI： 10.1021/jo061185g

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


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Authors:  Mohammad Movassaghi; Omar K Ahmad
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