Literature DB >> 1693002

Neuropeptide substance P improves water maze performance in aged rats.

R U Hasenöhrl1, J P Huston, T Schuurman.   

Abstract

The effects of the peripherally administered neuropeptide substance P (SP) on spatial learning capacities were investigated in 27-month-old rats using a water-maze task. Old rats were injected intraperitoneally once daily for 6 days with 50 or 250 micrograms/kg SP or vehicle 30 min prior to acquisition trials. Improvement in maze performance was observed following injections of 250 micrograms/kg SP only. Furthermore, vehicle-treated old rats showed significantly poorer acquisition rates than vehicle-treated 12-week-old rats. Thus, the improvement in performance after the 250 micrograms/kg dose of SP can be interpreted in terms of a compensation of performance deficit in the old rats.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 1693002     DOI： 10.1007/bf02253712

Source DB:  PubMed          Journal:  Psychopharmacology (Berl)        ISSN： 0033-3158            Impact factor:   4.530


  12 in total

1.  Substance P enhancement of inhibitory avoidance learning: mediation by the N-terminal sequence.

Authors:  R U Hasenöhrl; P Gerhardt; J P Huston
Journal:  Peptides       Date:  1990 Jan-Feb       Impact factor: 3.750

Review 2.  Spatial learning deficits in old rats: a model for memory decline in the aged.

Authors:  M Gallagher; M A Pelleymounter
Journal:  Neurobiol Aging       Date:  1988 Sep-Dec       Impact factor: 4.673

Review 3.  The relationship between reinforcement and memory: parallels in the rewarding and mnemonic effects of the neuropeptide substance P.

Authors:  J P Huston; M S Oitzl
Journal:  Neurosci Biobehav Rev       Date:  1989 Summer-Fall       Impact factor: 8.989

4.  Analysis of age-related impairments in learning and memory in rodent models.

Authors:  D K Ingram
Journal:  Ann N Y Acad Sci       Date:  1985       Impact factor: 5.691

5.  Age-related behavioral and neurobiological changes: a review with an emphasis on memory.

Authors:  P Kubanis; S F Zornetzer
Journal:  Behav Neural Biol       Date:  1981-02

6.  Nonparametric analysis of response curves.

Authors:  J Krauth
Journal:  J Neurosci Methods       Date:  1980-06       Impact factor: 2.390

7.  Reinforcing effects of peripherally administered substance P and its C-terminal sequence pGlu6-SP6-11 in the rat.

Authors:  M S Oitzl; R U Hasenöhrl; J P Huston
Journal:  Psychopharmacology (Berl)       Date:  1990       Impact factor: 4.530

8.  A reduction in the concentration of immunoreactive corticotropin, melanotropin and lipotropin in the brain of the aging rat.

Authors:  A Barnea; G Cho; J C Porter
Journal:  Brain Res       Date:  1982-01-28       Impact factor: 3.252

9.  Peptides and the blood-brain barrier: lipophilicity as a predictor of permeability.

Authors:  W A Banks; A J Kastin
Journal:  Brain Res Bull       Date:  1985-09       Impact factor: 4.077

Review 10.  Drug influences on learning and memory in aged animals and humans.

Authors:  F J Hock
Journal:  Neuropsychobiology       Date:  1987       Impact factor: 2.328
View more
  7 in total

1.  Further evidence for a dissociation between different forms of mnemonic expressions in a mouse model of age-related cognitive decline: effects of tacrine and S 17092, a novel prolyl endopeptidase inhibitor.

Authors:  A Marighetto; K Touzani; N Etchamendy; C C Torrea; G De Nanteuil; D Guez; R Jaffard; P Morain
Journal:  Learn Mem       Date:  2000 May-Jun       Impact factor: 2.460

2.  Effect of a novel prolyl endopeptidase inhibitor, JTP-4819, on neuropeptide metabolism in the rat brain.

Authors:  K Toide; T Fujiwara; Y Iwamoto; M Shinoda; K Okamiya; T Kato
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1996-02       Impact factor: 3.000

3.  Neurokinin3 receptor as a target to predict and improve learning and memory in the aged organism.

Authors:  Maria A de Souza Silva; Bernd Lenz; Andrea Rotter; Teresa Biermann; Oliver Peters; Alfredo Ramirez; Frank Jessen; Wolfgang Maier; Michael Hüll; Johannes Schröder; Lutz Frölich; Stefan Teipel; Oliver Gruber; Johannes Kornhuber; Joseph P Huston; Christian P Müller; Sandra Schäble
Journal:  Proc Natl Acad Sci U S A       Date:  2013-08-27       Impact factor: 11.205

Review 4.  Sequence-specific effects of neurokinin substance P on memory, reinforcement, and brain dopamine activity.

Authors:  J P Huston; R U Hasenöhrl; F Boix; P Gerhardt; R K Schwarting
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

5.  Disruption of the neurokinin-3 receptor (NK3) in mice leads to cognitive deficits.

Authors:  Judith A Siuciak; Sheryl A McCarthy; A N Martin; D S Chapin; J Stock; D M Nadeau; S Kantesaria; D Bryce-Pritt; S McLean
Journal:  Psychopharmacology (Berl)       Date:  2007-06-10       Impact factor: 4.415

6.  Systemic administration of substance P recovers beta amyloid-induced cognitive deficits in rat: involvement of Kv potassium channels.

Authors:  Patrizia Campolongo; Patrizia Ratano; Maria Teresa Ciotti; Fulvio Florenzano; Stefania Lucia Nori; Roberta Marolda; Maura Palmery; Anna Maria Rinaldi; Cristina Zona; Roberta Possenti; Pietro Calissano; Cinzia Severini
Journal:  PLoS One       Date:  2013-11-12       Impact factor: 3.240

7.  Immunohistochemical and behaviour pharmacological analysis of rats inoculated intranasally with vesicular stomatitis virus.

Authors:  T Andersson; A K Mohammed; B G Henriksson; C Wickman; E Norrby; M Schultzberg; K Kristensson
Journal:  J Chem Neuroanat       Date:  1993 Jan-Feb       Impact factor: 3.052
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.