Literature DB >> 16928966

What does detection of Mycobacterium ulcerans DNA in the margin of an excised Buruli ulcer lesion tell us?

Simona Rondini1, Ernestina Mensah-Quainoo, Thomas Junghanss, Gerd Pluschke.   

Abstract

We determined by real-time PCR the distribution of Mycobacterium ulcerans DNA in the excised lesion of a Buruli ulcer patient. A new lesion developed adjacent to the site of excision in the patient. The excised margin around the primary lesion contained a small amount of mycobacterial DNA in the area where the secondary lesion developed. These results suggest that a relatively small number of infiltrating mycobacteria can lead to the development of a recurrence.

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Year:  2006        PMID： 16928966      PMCID： PMC1698343          DOI： 10.1128/JCM.00970-06

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  11 in total

1.  A Mycobacterium ulcerans toxin, mycolactone, causes apoptosis in guinea pig ulcers and tissue culture cells.

Authors:  K M George; L Pascopella; D M Welty; P L Small
Journal:  Infect Immun       Date:  2000-02       Impact factor: 3.441

2.  Susceptibility to Buruli ulcer is associated with the SLC11A1 (NRAMP1) D543N polymorphism.

Authors:  Y Stienstra; T S van der Werf; E Oosterom; I M Nolte; W T A van der Graaf; S Etuaful; P L Raghunathan; E A S Whitney; E O Ampadu; K Asamoa; E Y Klutse; G J te Meerman; J W Tappero; D A Ashford; G van der Steege
Journal:  Genes Immun       Date:  2006-04       Impact factor: 2.676

3.  Mycolactone: a polyketide toxin from Mycobacterium ulcerans required for virulence.

Authors:  K M George; D Chatterjee; G Gunawardana; D Welty; J Hayman; R Lee; P L Small
Journal:  Science       Date:  1999-02-05       Impact factor: 47.728

4.  Genetic diversity in Mycobacterium ulcerans isolates from Ghana revealed by a newly identified locus containing a variable number of tandem repeats.

Authors:  Markus Hilty; Dorothy Yeboah-Manu; Daniel Boakye; Ernestina Mensah-Quainoo; Simona Rondini; Esther Schelling; David Ofori-Adjei; Françoise Portaels; Jakob Zinsstag; Gerd Pluschke
Journal:  J Bacteriol       Date:  2006-02       Impact factor: 3.490

5.  Contiguous spread of Mycobacterium ulcerans in Buruli ulcer lesions analysed by histopathology and real-time PCR quantification of mycobacterial DNA.

Authors:  Simona Rondini; Catherine Horsfield; Ernestina Mensah-Quainoo; Thomas Junghanss; Sebastian Lucas; Gerd Pluschke
Journal:  J Pathol       Date:  2006-01       Impact factor: 7.996

6.  Post-surgical assessment of excised tissue from patients with Buruli ulcer disease: progression of infection in macroscopically healthy tissue.

Authors:  G Bretzel; V Siegmund; P Racz; F van Vloten; F Ngos; W Thompson; P Biason; O Adjei; B Fleischer; J Nitschke
Journal:  Trop Med Int Health       Date:  2005-11       Impact factor: 2.622

7.  Buruli ulcer: differences in treatment outcome between two centres in Ghana.

Authors:  M A Teelken; Y Stienstra; D E Ellen; E Quarshie; E Klutse; W T A van der Graaf; Tjip S van der Werf
Journal:  Acta Trop       Date:  2003-09       Impact factor: 3.112

8.  Development and application of real-time PCR assay for quantification of Mycobacterium ulcerans DNA.

Authors:  S Rondini; E Mensah-Quainoo; H Troll; T Bodmer; G Pluschke
Journal:  J Clin Microbiol       Date:  2003-09       Impact factor: 5.948

9.  Buruli ulcer: a systemic disease.

Authors:  Nina Pszolla; Michael Robindra Sarkar; Wolf Strecker; Peter Kern; Lothar Kinzl; Wayne M Meyers; Françoise Portaels
Journal:  Clin Infect Dis       Date:  2003-08-26       Impact factor: 9.079

10.  Buruli ulcer recurrence, Benin.

Authors:  Martine Debacker; Julia Aguiar; Christian Steunou; Claude Zinsou; Wayne M Meyers; Françoise Portaels
Journal:  Emerg Infect Dis       Date:  2005-04       Impact factor: 6.883
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  3 in total

1.  Excision of pre-ulcerative forms of Buruli ulcer disease: a curative treatment?

Authors:  K-H Herbinger; D Brieske; J Nitschke; V Siegmund; W Thompson; E Klutse; N Y Awua-Boateng; E Bruhl; L Kunaa; M Schunk; O Adjei; T Löscher; G Bretzel
Journal:  Infection       Date:  2008-12-03       Impact factor: 3.553

2.  Cellular immunity confers transient protection in experimental Buruli ulcer following BCG or mycolactone-negative Mycobacterium ulcerans vaccination.

Authors:  Alexandra G Fraga; Teresa G Martins; Egídio Torrado; Kris Huygen; Françoise Portaels; Manuel T Silva; António G Castro; Jorge Pedrosa
Journal:  PLoS One       Date:  2012-03-08       Impact factor: 3.240

3.  Development of a dry-reagent-based qPCR to facilitate the diagnosis of Mycobacterium ulcerans infection in endemic countries.

Authors:  Jérémie Babonneau; Christian Bernard; Estelle Marion; Annick Chauty; Marie Kempf; Raymond Robert; Laurent Marsollier
Journal:  PLoS Negl Trop Dis       Date:  2015-04-01
  3 in total

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