Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Concise total synthesis of the marine natural product ageladine A.

Literature DB >> 16928079

Concise total synthesis of the marine natural product ageladine A.

Abstract

A total synthesis of ageladine A has been achieved by exploiting a Pictet-Spengler-type condensation between 2-aminohistamine and 4,5-dibromo-2-formylpyrrole as the key step.

Entities: Chemical

Mesh：

Substances：
Ageladine A
Pyrroles

Year: 2006 PMID： 16928079 DOI： 10.1021/ol061584y

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

Keyword Cloud
Cited

7 in total

1. Synthesis and anticancer activities of ageladine A and structural analogs.

Authors: Yuelong Ma; Sangkil Nam; Richard Jove; Kenichi Yakushijin; David A Horne
Journal: Bioorg Med Chem Lett Date: 2009-11-14 Impact factor: 2.823

2. The alkaloid Ageladine A, originally isolated from marine sponges, used for pH-sensitive imaging of transparent marine animals.

Authors: Ulf Bickmeyer
Journal: Mar Drugs Date: 2012-01-19 Impact factor: 6.085

3. The chemically synthesized ageladine A-derivative LysoGlow84 stains lysosomes in viable mammalian brain cells and specific structures in the marine flatworm Macrostomum lignano.

Authors: Thorsten Mordhorst; Sushil Awal; Sebastian Jordan; Charlotte Petters; Linda Sartoris; Ralf Dringen; Ulf Bickmeyer
Journal: Mar Drugs Date: 2015-02-11 Impact factor: 5.118

7. Reporter dyes demonstrate functional expression of multidrug resistance proteins in the marine flatworm Macrostomum lignano: the sponge-derived dye Ageladine A is not a substrate of these transporters.

Authors: Kristin Tietje; Georgina Rivera-Ingraham; Charlotte Petters; Doris Abele; Ralf Dringen; Ulf Bickmeyer
Journal: Mar Drugs Date: 2013-10-16 Impact factor: 5.118

7 in total

Concise total synthesis of the marine natural product ageladine A.

1. Synthesis and anticancer activities of ageladine A and structural analogs.

2. The alkaloid Ageladine A, originally isolated from marine sponges, used for pH-sensitive imaging of transparent marine animals.

3. The chemically synthesized ageladine A-derivative LysoGlow84 stains lysosomes in viable mammalian brain cells and specific structures in the marine flatworm Macrostomum lignano.

4. Enhancement of photosynthesis in Synechococcus bacillaris by sponge-derived Ageladine A.

Review 5. A submarine journey: the pyrrole-imidazole alkaloids.

Review 6. Marine-derived angiogenesis inhibitors for cancer therapy.

7. Reporter dyes demonstrate functional expression of multidrug resistance proteins in the marine flatworm Macrostomum lignano: the sponge-derived dye Ageladine A is not a substrate of these transporters.