| Literature DB >> 16928063 |
Laurent El Kaim1, Marie Gizolme, Laurence Grimaud, Julie Oble.
Abstract
New heterocyclic scaffolds can be easily prepared by the coupling of heteroaromatic phenols (pyridines, pyrimidines) with carbonyl compounds, amines, and isocyanides. This transformation related to the Ugi reaction probably involves a Smiles rearrangement. The scope of this methodology is further extended by the successful use of heterocyclic thiols to form highly functionalized thioamides.Entities:
Year: 2006 PMID： 16928063 DOI： 10.1021/ol061605o
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005