Literature DB >> 1692774

CD4+ cells treated with DNA methylation inhibitors induce autologous B cell differentiation.

B C Richardson1, M R Liebling, J L Hudson.   

Abstract

The DNA methylation inhibitor 5-azacytidine induces autoreactivity in cloned CD4+ T cells, but the functional consequences of this response are unknown. We now report that CD4+ T cells treated with 5-azacytidine respond to autologous antigen-presenting cells and induce autologous B cell differentiation without exogenous antigen or mitogen. This mechanism could play a role in some autoimmune diseases characterized by T cell DNA hypomethylation and polyclonal B cell activation.

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Year:  1990        PMID： 1692774     DOI： 10.1016/0090-1229(90)90125-a

Source DB:  PubMed          Journal:  Clin Immunol Immunopathol        ISSN： 0090-1229


  16 in total

1.  Analysis of human peripheral blood T cells and single-cell-derived T cell clones uncovers extensive clonal CpG island methylation heterogeneity throughout the genome.

Authors:  X Zhu; C Deng; R Kuick; R Yung; B Lamb; J V Neel; B Richardson; S Hanash
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-06       Impact factor: 11.205

2.  Ultraviolet B decreases DNA methylation level of CD4+ T cells in patients with systemic lupus erythematosus.

Authors:  Min Zhang; Xuan Fang; Guo-Sheng Wang; Yan Ma; Li Jin; Xiao-Mei Li; Xiang-Pei Li
Journal:  Inflammopharmacology       Date:  2017-02-11       Impact factor: 4.473

3.  Alteration of DNA methylation levels in MRL lupus mice.

Authors:  M Mizugaki; T Yamaguchi; S Ishiwata; H Shindo; T Hishinuma; S Nozaki; M Nose
Journal:  Clin Exp Immunol       Date:  1997-11       Impact factor: 4.330

4.  Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice.

Authors:  J Quddus; K J Johnson; J Gavalchin; E P Amento; C E Chrisp; R L Yung; B C Richardson
Journal:  J Clin Invest       Date:  1993-07       Impact factor: 14.808

Review 5.  Key role of ERK pathway signaling in lupus.

Authors:  Gabriela Gorelik; Bruce Richardson
Journal:  Autoimmunity       Date:  2010-02       Impact factor: 2.815

Review 6.  Epigenetic control of cytokine gene expression: regulation of the TNF/LT locus and T helper cell differentiation.

Authors:  James V Falvo; Luke D Jasenosky; Laurens Kruidenier; Anne E Goldfeld
Journal:  Adv Immunol       Date:  2013       Impact factor: 3.543

7.  Murine models of lupus induced by hypomethylated T cells.

Authors:  Bruce Richardson; Donna Ray; Raymond Yung
Journal:  Methods Mol Med       Date:  2004

Review 8.  Epigenetics in human autoimmunity. Epigenetics in autoimmunity - DNA methylation in systemic lupus erythematosus and beyond.

Authors:  Faith M Strickland; Bruce C Richardson
Journal:  Autoimmunity       Date:  2008-05       Impact factor: 2.815

9.  Single nucleotide polymorphism in DNMT3B promoter and the risk for idiopathic thrombocytopenic purpura in Chinese population.

Authors:  Zhenping Chen; Zeping Zhou; Xiaoli Chen; Jianhui Xu; Aijuan Liu; Weiting Du; Dongsheng Gu; Jing Ge; Zhenxing Guo; Xiaoyan Wang; Xunwei Dong; Qian Ren; Renchi Yang
Journal:  J Clin Immunol       Date:  2008-04-25       Impact factor: 8.317

10.  RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1.

Authors:  Ming Zhao; Xiaoyan Wu; Qing Zhang; Shuangyan Luo; Gongping Liang; Yuwen Su; Yixin Tan; Qianjin Lu
Journal:  Arthritis Res Ther       Date:  2010-12-30       Impact factor: 5.156
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