Literature DB >> 16927527

Molecular mechanisms underlying the immunomodulatory effects of mistletoe (Viscum album L.) extracts Iscador.

Sriramulu Elluru1, Jean-Paul Duong Van Huyen, Sandrine Delignat, Fabienne Prost, Jagadeesh Bayry, Michel D Kazatchkine, Srini V Kaveri.   

Abstract

Viscum album (VA) preparations (Iscador) consist of aqueous extracts from different types of European mistletoe. Biologically active components of VA extracts include mistletoe lectins (ML) and viscotoxins. The treatment with VA extracts or with purified ML has been shown to be associated with tumor regression in several in vivo experimental models of tumoral implantation. The mechanisms underlying the anti-tumoral activity of VA or ML are complex and involve apoptosis, angiogenesis and immunomodulation. This review provides an account of the current status of the understanding of the VA-associated immunomodulation in various cell types including lymphoblastoid, monocytic or endothelial cell lines.

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Year:  2006        PMID： 16927527     DOI： 10.1055/s-0031-1296813

Source DB:  PubMed          Journal:  Arzneimittelforschung        ISSN： 0004-4172


  8 in total

Review 1.  Phytotherapy in Integrative Oncology-An Update of Promising Treatment Options.

Authors:  Amy M Zimmermann-Klemd; Jakob K Reinhardt; Moritz Winker; Carsten Gründemann
Journal:  Molecules       Date:  2022-05-17       Impact factor: 4.927

2.  Viscum album-mediated COX-2 inhibition implicates destabilization of COX-2 mRNA.

Authors:  Chaitrali Saha; Pushpa Hegde; Alain Friboulet; Jagadeesh Bayry; Srinivas V Kaveri
Journal:  PLoS One       Date:  2015-02-09       Impact factor: 3.240

3.  Immunomodulatory Effect of Gymnema sylvestre (R.Br.) Leaf Extract: An In Vitro Study in Rat Model.

Authors:  Vineet Kumar Singh; Padmanabh Dwivedi; B R Chaudhary; Ramesh Singh
Journal:  PLoS One       Date:  2015-10-16       Impact factor: 3.240

4.  Synergistic Antitumour Properties of viscumTT in Alveolar Rhabdomyosarcoma.

Authors:  Rahel Mascha Stammer; Susann Kleinsimon; Jana Rolff; Sebastian Jäger; Angelika Eggert; Georg Seifert; Catharina I Delebinski
Journal:  J Immunol Res       Date:  2017-07-16       Impact factor: 4.818

5.  Mistletoe-Based Drugs Work in Synergy with Radio-Chemotherapy in the Treatment of Glioma In Vitro and In Vivo in Glioblastoma Bearing Mice.

Authors:  Sonja Schötterl; Jennifer T Miemietz; Elena I Ilina; Naita M Wirsik; Ingrid Ehrlich; Andrea Gall; Stephan M Huber; Hans Lentzen; Michel Mittelbronn; Ulrike Naumann
Journal:  Evid Based Complement Alternat Med       Date:  2019-07-03       Impact factor: 2.629

6.  Induction of maturation and activation of human dendritic cells: a mechanism underlying the beneficial effect of Viscum album as complimentary therapy in cancer.

Authors:  Sri Ramulu Elluru; Jean-Paul Duong van Huyen; Sandrine Delignat; Michel D Kazatchkine; Alain Friboulet; Srini V Kaveri; Jagadeesh Bayry
Journal:  BMC Cancer       Date:  2008-06-04       Impact factor: 4.430

7.  NCCAM/NCI Phase 1 Study of Mistletoe Extract and Gemcitabine in Patients with Advanced Solid Tumors.

Authors:  Patrick J Mansky; Dawn B Wallerstedt; Timothy S Sannes; Jamie Stagl; Laura Lee Johnson; Marc R Blackman; Jean L Grem; Sandra M Swain; Brian P Monahan
Journal:  Evid Based Complement Alternat Med       Date:  2013-10-27       Impact factor: 2.629

8.  Adjuvant Therapy Using Mistletoe Containing Drugs Boosts the T-Cell-Mediated Killing of Glioma Cells and Prolongs the Survival of Glioma Bearing Mice.

Authors:  Sonja Schötterl; Stephan M Huber; Hans Lentzen; Michel Mittelbronn; Ulrike Naumann
Journal:  Evid Based Complement Alternat Med       Date:  2018-08-27       Impact factor: 2.629
  8 in total

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