BACKGROUND AND OBJECTIVES: Multidrug resistant tuberculosis (MDR-TB) has been a cause of concern in both developed and developing countries. Surveillance data on primary drug resistance in Mycobacterium tuberculosis are important to design tuberculosis control programmes. There is a paucity of information about primary drug resistance in mycobacterium in Iran. We undertook this hospital-based study to assess the prevalence of primary of drug resistant in M. tuberculosis in Mashhad, Iran. METHODS: A total of 105 M. tuberculosis isolates from cases with pulmonary and extrapulmonary tuberculosis, who did not have prior history of anti-tuberculosis treatment, were tested for the drug susceptibility by indirect proportion susceptibility test as per the standard guidelines. RESULTS: Of the 105 isolate tested, 93 were from pulmonary specimens; and the remaining were extrapulmonary. 79.6 per cent of pulmonary and 50 per cent of extrapulmonary specimens were smear positive. Resistance to at least one drug was shown by 29.5 per cent, while 2.9 per cent were resistant to more than one drug. MDR-TB was found at 1 per cent of strains. INTERPRETATION AND CONCLUSION: Our study showed a high level of resistance to streptomycin and very low resistance to other drugs. To achieve the higher cure rate, replacement of streptomycin by ethambutol and strict implementation of DOTs may be considered.
BACKGROUND AND OBJECTIVES: Multidrug resistant tuberculosis (MDR-TB) has been a cause of concern in both developed and developing countries. Surveillance data on primary drug resistance in Mycobacterium tuberculosis are important to design tuberculosis control programmes. There is a paucity of information about primary drug resistance in mycobacterium in Iran. We undertook this hospital-based study to assess the prevalence of primary of drug resistant in M. tuberculosis in Mashhad, Iran. METHODS: A total of 105 M. tuberculosis isolates from cases with pulmonary and extrapulmonary tuberculosis, who did not have prior history of anti-tuberculosis treatment, were tested for the drug susceptibility by indirect proportion susceptibility test as per the standard guidelines. RESULTS: Of the 105 isolate tested, 93 were from pulmonary specimens; and the remaining were extrapulmonary. 79.6 per cent of pulmonary and 50 per cent of extrapulmonary specimens were smear positive. Resistance to at least one drug was shown by 29.5 per cent, while 2.9 per cent were resistant to more than one drug. MDR-TB was found at 1 per cent of strains. INTERPRETATION AND CONCLUSION: Our study showed a high level of resistance to streptomycin and very low resistance to other drugs. To achieve the higher cure rate, replacement of streptomycin by ethambutol and strict implementation of DOTs may be considered.
Authors: Mohammad Javad Nasiri; Abbas Ali Imani Fooladi; Hossein Dabiri; Ali Pormohammad; Alireza Salimi Chirani; Masoud Dadashi; Hamidreza Houri; Mohsen Heidary; Mohammad Mehdi Feizabadi Journal: Ther Adv Infect Dis Date: 2016-08-10
Authors: M J Nasiri; S Zamani; A Pormohammad; M M Feizabadi; H R Aslani; M Amin; R Halabian; A A Imani Fooladi Journal: Eur J Clin Microbiol Infect Dis Date: 2017-08-19 Impact factor: 3.267
Authors: Ahmad Reza Bahrmand; Leonid P Titov; Alireza Hadizadeh Tasbiti; Shamsi Yari; Edward A Graviss Journal: J Clin Microbiol Date: 2009-09 Impact factor: 5.948
Authors: Kimia Taghavi; Parissa Farnia; Mohammad Varahram; Fatemeh Maryam Sheikhoslami; Mojtaba Ahmadi; Mehdi Kazempoor; Mohammad Reza Masjedi; Ali Akbar Velayati Journal: Cell J Date: 2011-08-24 Impact factor: 2.479