Literature DB >> 16924470

Decompartmentalizing target validation-thinking outside the pipeline boxes.

Rob Hooft van Huijsduijnen1, Christian Rommel.   

Abstract

Mesh：

Year:  2006        PMID： 16924470     DOI： 10.1007/s00109-006-0080-2

Source DB:  PubMed          Journal:  J Mol Med (Berl)        ISSN： 0946-2716            Impact factor:   4.599


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  45 in total

Review 1.  Cre recombinase: the universal reagent for genome tailoring.

Authors:  A Nagy
Journal:  Genesis       Date:  2000-02       Impact factor: 2.487

Review 2.  Novel chemical genetic approaches to the discovery of signal transduction inhibitors.

Authors:  Kevan Shokat; Mark Velleca
Journal:  Drug Discov Today       Date:  2002-08-15       Impact factor: 7.851

Review 3.  Predicting drug efficacy: knockouts model pipeline drugs of the pharmaceutical industry.

Authors:  Brian P Zambrowicz; C Alexander Turner; Arthur T Sands
Journal:  Curr Opin Pharmacol       Date:  2003-10       Impact factor: 5.547

4.  Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

Authors:  Montserrat Camps; Thomas Rückle; Hong Ji; Vittoria Ardissone; Felix Rintelen; Jeffrey Shaw; Chiara Ferrandi; Christian Chabert; Corine Gillieron; Bernard Françon; Thierry Martin; Denise Gretener; Dominique Perrin; Didier Leroy; Pierre-Alain Vitte; Emilio Hirsch; Matthias P Wymann; Rocco Cirillo; Matthias K Schwarz; Christian Rommel
Journal:  Nat Med       Date:  2005-08-28       Impact factor: 53.440

5.  PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus.

Authors:  Domingo F Barber; Almira Bartolomé; Carmen Hernandez; Juana M Flores; Clara Redondo; Cristina Fernandez-Arias; Montserrat Camps; Thomas Rückle; Matthias K Schwarz; Santiago Rodríguez; Carlos Martinez-A; Dimitrios Balomenos; Christian Rommel; Ana C Carrera
Journal:  Nat Med       Date:  2005-08-28       Impact factor: 53.440

6.  Pivotal role of Harakiri in the induction and prevention of gentamicin-induced hearing loss.

Authors:  Gilda M Kalinec; Martin E Fernandez-Zapico; Raul Urrutia; Nora Esteban-Cruciani; Shanping Chen; Federico Kalinec
Journal:  Proc Natl Acad Sci U S A       Date:  2005-10-20       Impact factor: 11.205

7.  Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes.

Authors:  R D Palmiter; R L Brinster; R E Hammer; M E Trumbauer; M G Rosenfeld; N C Birnberg; R M Evans
Journal:  Nature       Date:  1982-12-16       Impact factor: 49.962

8.  A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.

Authors:  Ann B Begovich; Victoria E H Carlton; Lee A Honigberg; Steven J Schrodi; Anand P Chokkalingam; Heather C Alexander; Kristin G Ardlie; Qiqing Huang; Ashley M Smith; Jill M Spoerke; Marion T Conn; Monica Chang; Sheng-Yung P Chang; Randall K Saiki; Joseph J Catanese; Diane U Leong; Veronica E Garcia; Linda B McAllister; Douglas A Jeffery; Annette T Lee; Franak Batliwalla; Elaine Remmers; Lindsey A Criswell; Michael F Seldin; Daniel L Kastner; Christopher I Amos; John J Sninsky; Peter K Gregersen
Journal:  Am J Hum Genet       Date:  2004-06-18       Impact factor: 11.025

9.  Evidence for a functional second thymus in mice.

Authors:  Grzegorz Terszowski; Susanna M Müller; Conrad C Bleul; Carmen Blum; Reinhold Schirmbeck; Jörg Reimann; Louis Du Pasquier; Takashi Amagai; Thomas Boehm; Hans-Reimer Rodewald
Journal:  Science       Date:  2006-03-02       Impact factor: 47.728

10.  PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects.

Authors:  Enrico Patrucco; Antonella Notte; Laura Barberis; Giulio Selvetella; Angelo Maffei; Mara Brancaccio; Stefano Marengo; Giovanni Russo; Ornella Azzolino; Sergei D Rybalkin; Lorenzo Silengo; Fiorella Altruda; Reinhard Wetzker; Matthias P Wymann; Giuseppe Lembo; Emilio Hirsch
Journal:  Cell       Date:  2004-08-06       Impact factor: 41.582
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  1 in total

1.  GLEPP1/protein-tyrosine phosphatase phi inhibitors block chemotaxis in vitro and in vivo and improve murine ulcerative colitis.

Authors:  Rosanna Pescini Gobert; Monique van den Eijnden; Cedric Szyndralewiez; Catherine Jorand-Lebrun; Dominique Swinnen; Linfeng Chen; Corine Gillieron; Fiona Pixley; Pierre Juillard; Patrick Gerber; Caroline Johnson-Léger; Serge Halazy; Montserrat Camps; Agnes Bombrun; Margaret Shipp; Pierre-Alain Vitte; Vittoria Ardissone; Chiara Ferrandi; Dominique Perrin; Christian Rommel; Rob Hooft van Huijsduijnen
Journal:  J Biol Chem       Date:  2009-02-20       Impact factor: 5.157
  1 in total

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