| Literature DB >> 16924032 |
R M D Holsinger1, J S Lee, A Boyd, C L Masters, S J Collins.
Abstract
To assess the diagnostic utility of CSF BACE1 activity for discriminating Alzheimer disease (AD) from other dementias, particularly Creutzfeldt-Jakob disease (CJD), the authors studied 26 patients with sporadic CJD, 21 patients with AD, and 21 patients with various non-AD, non-CJD dementias (DCs). CSF BACE1 activity was elevated in AD in comparison with DC (p = 0.01). Unexpectedly, CSF BACE1 activity was also increased in sporadic CJD (p = 0.02).Entities:
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Year: 2006 PMID： 16924032 DOI： 10.1212/01.wnl.0000229925.52203.4c
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910