Literature DB >> 16924028

Increased rate of whole-brain atrophy over 6 months in early Huntington disease.

S M D Henley1, C Frost, D G MacManus, T T Warner, N C Fox, S J Tabrizi.   

Abstract

The authors measured the rate of whole-brain atrophy over 6 months in 13 patients with early Huntington disease (HD) and seven matched controls. Patients with early HD had significantly increased rates of whole-brain atrophy vs controls (mean [SD] HD, 1.10 [0.88]%/year; controls, 0.26 [0.54]%/year). The measurement of cerebral change over short time periods (e.g., 6 months) may be relevant for trials designed to assess effects on neurodegeneration or atrophy.

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Year:  2006        PMID： 16924028     DOI： 10.1212/01.wnl.0000230149.36635.c8

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  15 in total

1.  Early Detection of Huntington Disease.

Authors:  Jane S Paulsen
Journal:  Future Neurol       Date:  2010-01

Review 2.  Molecular medicine: predicting and preventing Huntington's disease.

Authors:  Ferdinando Squitieri; Milena Cannella; Luigi Frati
Journal:  Neurol Sci       Date:  2008-09-20       Impact factor: 3.307

Review 3.  Human brain changes across the life span: a review of 56 longitudinal magnetic resonance imaging studies.

Authors:  Anna M Hedman; Neeltje E M van Haren; Hugo G Schnack; René S Kahn; Hilleke E Hulshoff Pol
Journal:  Hum Brain Mapp       Date:  2011-09-13       Impact factor: 5.038

4.  Early atrophy of pallidum and accumbens nucleus in Huntington's disease.

Authors:  Simon J A van den Bogaard; Eve M Dumas; Tanka P Acharya; Hans Johnson; Douglas R Langbehn; Rachael I Scahill; Sarah J Tabrizi; Mark A van Buchem; Jeroen van der Grond; Raymund A C Roos
Journal:  J Neurol       Date:  2010-10-09       Impact factor: 4.849

5.  Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration.

Authors:  F Cicchetti; S Saporta; R A Hauser; M Parent; M Saint-Pierre; P R Sanberg; X J Li; J R Parker; Y Chu; E J Mufson; J H Kordower; T B Freeman
Journal:  Proc Natl Acad Sci U S A       Date:  2009-07-20       Impact factor: 11.205

6.  Magnetization transfer imaging in premanifest and manifest huntington disease: a 2-year follow-up.

Authors:  S J A van den Bogaard; E M Dumas; E P Hart; J Milles; R Reilmann; J C Stout; D Craufurd; C R Gibbard; S J Tabrizi; M A van Buchem; J van der Grond; R A C Roos
Journal:  AJNR Am J Neuroradiol       Date:  2012-08-23       Impact factor: 3.825

7.  Abnormal motor cortex plasticity in premanifest and very early manifest Huntington disease.

Authors:  Michael Orth; Sven Schippling; Susanne A Schneider; Kailash P Bhatia; Penelope Talelli; Sarah J Tabrizi; John C Rothwell
Journal:  J Neurol Neurosurg Psychiatry       Date:  2009-10-13       Impact factor: 10.154

8.  Abnormal motor cortex excitability in preclinical and very early Huntington's disease.

Authors:  Sven Schippling; Susanne A Schneider; Khailash P Bhatia; Alexander Münchau; John C Rothwell; Sarah J Tabrizi; Michael Orth
Journal:  Biol Psychiatry       Date:  2009-02-07       Impact factor: 13.382

9.  Robust atrophy rate measurement in Alzheimer's disease using multi-site serial MRI: tissue-specific intensity normalization and parameter selection.

Authors:  Kelvin K Leung; Matthew J Clarkson; Jonathan W Bartlett; Shona Clegg; Clifford R Jack; Michael W Weiner; Nick C Fox; Sébastien Ourselin
Journal:  Neuroimage       Date:  2009-12-23       Impact factor: 6.556

Review 10.  Magnetic resonance imaging of Huntington's disease: preparing for clinical trials.

Authors:  S Klöppel; S M Henley; N Z Hobbs; R C Wolf; J Kassubek; S J Tabrizi; R S J Frackowiak
Journal:  Neuroscience       Date:  2009-01-29       Impact factor: 3.590
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