Literature DB >> 16923914

Genetic evidence for an interaction of the UbiG O-methyltransferase with UbiX in Escherichia coli coenzyme Q biosynthesis.

Melissa Gulmezian1, Haitao Zhang, George T Javor, Catherine F Clarke.   

Abstract

IS16 is a thiol-sensitive, Q-deficient mutant strain of Escherichia coli. Here, we show that IS16 harbors a mutation in the ubiG gene encoding a methyltransferase required for two O-methylation steps of Q biosynthesis. Complementation of IS16 with either ubiG or ubiX(K-12) reverses this phenotype, suggesting that UbiX may interact with UbiG.

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Year:  2006        PMID: 16923914      PMCID: PMC1595381          DOI: 10.1128/JB.00668-06

Source DB:  PubMed          Journal:  J Bacteriol        ISSN: 0021-9193            Impact factor:   3.490


  31 in total

1.  Identification of the ubiD gene on the Escherichia coli chromosome.

Authors:  H Zhang; G T Javor
Journal:  J Bacteriol       Date:  2000-11       Impact factor: 3.490

2.  Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis.

Authors:  Chih-chin Huang; Clare V Smith; Michael S Glickman; William R Jacobs; James C Sacchettini
Journal:  J Biol Chem       Date:  2001-12-26       Impact factor: 5.157

3.  Isolation and functional expression of human COQ3, a gene encoding a methyltransferase required for ubiquinone biosynthesis.

Authors:  T Jonassen; C F Clarke
Journal:  J Biol Chem       Date:  2000-04-28       Impact factor: 5.157

4.  Uncoupling the pleiotropic phenotypes of clk-1 with tRNA missense suppressors in Caenorhabditis elegans.

Authors:  Robyn Branicky; Phuong Anh Thi Nguyen; Siegfried Hekimi
Journal:  Mol Cell Biol       Date:  2006-05       Impact factor: 4.272

Review 5.  Ubiquinone biosynthesis in microorganisms.

Authors:  R Meganathan
Journal:  FEMS Microbiol Lett       Date:  2001-09-25       Impact factor: 2.742

6.  Genetic evidence for a multi-subunit complex in the O-methyltransferase steps of coenzyme Q biosynthesis.

Authors:  A Y Hsu; T Q Do; P T Lee; C F Clarke
Journal:  Biochim Biophys Acta       Date:  2000-04-12

7.  Biosynthesis, bioproduction and novel roles of ubiquinone.

Authors:  Makoto Kawamukai
Journal:  J Biosci Bioeng       Date:  2002       Impact factor: 2.894

8.  Automated identification of putative methyltransferases from genomic open reading frames.

Authors:  Jonathan E Katz; Mensur Dlakić; Steven Clarke
Journal:  Mol Cell Proteomics       Date:  2003-07-18       Impact factor: 5.911

9.  Yeast Coq5 C-methyltransferase is required for stability of other polypeptides involved in coenzyme Q biosynthesis.

Authors:  Suzie W Baba; Grigory I Belogrudov; Justine C Lee; Peter T Lee; Jeff Strahan; Jennifer N Shepherd; Catherine F Clarke
Journal:  J Biol Chem       Date:  2003-12-29       Impact factor: 5.157

10.  3-Hexaprenyl-4-hydroxybenzoic acid forms a predominant intermediate pool in ubiquinone biosynthesis in Saccharomyces cerevisiae.

Authors:  W W Poon; B N Marbois; K F Faull; C F Clarke
Journal:  Arch Biochem Biophys       Date:  1995-07-10       Impact factor: 4.013

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  4 in total

1.  Crystallization and preliminary crystallographic studies of UbiG, an O-methyltransferase from Escherichia coli.

Authors:  Li Xing; Yuwei Zhu; Pengfei Fang; Jing Wang; Fuxing Zeng; Xuesong Li; Maikun Teng; Xu Li
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2011-05-26

2.  Chorismate pyruvate-lyase and 4-hydroxy-3-solanesylbenzoate decarboxylase are required for plastoquinone biosynthesis in the cyanobacterium Synechocystis sp. PCC6803.

Authors:  Christian Pfaff; Niels Glindemann; Jens Gruber; Margrit Frentzen; Radin Sadre
Journal:  J Biol Chem       Date:  2013-12-11       Impact factor: 5.157

3.  The role of UbiX in Escherichia coli coenzyme Q biosynthesis.

Authors:  Melissa Gulmezian; Kyle R Hyman; Beth N Marbois; Catherine F Clarke; George T Javor
Journal:  Arch Biochem Biophys       Date:  2007-08-23       Impact factor: 4.013

4.  Biosynthesis of Menaquinone (Vitamin K2) and Ubiquinone (Coenzyme Q).

Authors:  R Meganathan; Ohsuk Kwon
Journal:  EcoSal Plus       Date:  2009-08
  4 in total

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