The relationship of low birth weight to blood pressure, cortisol levels, and reactivity in African American adolescents: a pilot study.

Epidemiological studies show a relationship between low birth weight (LBW) and adult cardiovascular disease. Blood pressure and cortisol hyper-responsiveness during physiologic stress may function as biological markers for hypertension. The purpose of this study was to explore the relationship of blood pressure and cortisol levels with induced physiologic stress to LBW. Forty-eight adolescents, 14 to 16 years old, were tested for blood pressure and cortisol levels at rest and in response to a physiological stressor. A history of LBW was obtained. Multivariate repeated measures analysis and chi-square analyses were used to determine the changes in blood pressure and cortisol.Forty-eight African American adolescents, mean age 14.98 years (SD = 0.33), completed the study. Thirteen adolescents (27%) reported LBW. Although not statistically significant, systolic and diastolic pressures were 6 mmHg and 2 mmHg, respectively, higher in the LBW group when compared with the normal birth weight (NBW) group (p = 0.33 and p = 0.21, and 6 (46%) had elevated blood pressures (p = 0.005)). Blood pressure changes, cardiovascular reactivity, elevated blood, or all of these were significantly higher in LBW African American adolescents (p = 0.006). Cardiovascular reactivity was not significant (p = 0.208)). The mean average cortisol levels were (18.8 nmol/dL (SD = 11.0) but comparable (p = 0.72)). The number of LBW adolescents with cortisol reactivity was significantly higher that in the NBW group (p = 0.041). This study adds support to the association of LBW to biological markers of hypertension in childhood.