| Literature DB >> 16923553 |
M J Greenwood1, M D Seftel, C Richardson, D Barbaric, M J Barnett, H Bruyere, D L Forrest, D E Horsman, C Smith, K Song, H J Sutherland, C L Toze, T J Nevill, S H Nantel, D E Hogge.
Abstract
Acute myeloid leukemia (AML) presenting with a high leukocyte count has been associated with an increase in induction mortality and poor results in a number of other survival measures. However, the level at which an elevated leukocyte count has prognostic significance in AML remains unclear. In this report on a series of 375 adult (non-M3) AML patients undergoing induction chemotherapy at a single institution, leukocyte count analyzed as a continuous variable is shown to be a better predictor of induction death (ID) and overall survival (OS) than a leukocyte count of > or = 100 x 10(9)/L, a value characteristically associated with "hyperleukocytosis" (HL). In this patient cohort, a presenting leukocyte count of > or = 30 x 10(9)/L had high sensitivity and specificity for predicting ID, and both performance status (PS) and leukocyte count more accurately predicted for ID than age. Considering these parameters in newly-diagnosed AML patients may facilitate the development of strategies for reducing induction mortality.Entities:
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Year: 2006 PMID： 16923553 DOI： 10.1080/10428190600572673
Source DB: PubMed Journal: Leuk Lymphoma ISSN： 1026-8022