| Literature DB >> 16923518 |
Kiyoshi Kitano1, Yukio Gibo, Atsushi Kamijo, Kiyoshi Furuta, Satohiro Oguchi, Satoru Joshita, Yasufumi Takahashi, Fumihiro Ishida, Masanori Matsumoto, Masahito Uemura, Yoshihiro Fujimura.
Abstract
A deficiency of ADAMTS13 leads to platelet clumping and/or thrombi formation, finally resulting in thrombotic thrombocytopenic purpura (TTP). In this study, a 62-year-old male with chronic hepatitis C developed TTP a month after long-term pegylated-interferon (PEG-IFN) treatment. The observed low level of activity of plasma ADAMTS13 following PEG-IFN treatment was shown to gradually increase with the improvement of TTP, while the titer of an inhibitory anti- ADAMTS13 IgG antibody decreased concomitant with the increase in ADAMTS13 activity. Serial determination of ADAMTS13 activity and its inhibitor may provide useful information for the diagnosis and treatment of IFN-associated TTP, as well as its pathogenesis.Entities:
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Year: 2006 PMID： 16923518
Source DB: PubMed Journal: Haematologica ISSN： 0390-6078 Impact factor: 9.941