| Literature DB >> 16923387 |
Yasunori Ogura1, Fayyaz S Sutterwala, Richard A Flavell.
Abstract
The NALP3-inflammasome is a protein complex that stimulates caspase-1 activation to promote the processing and secretion of proinflammatory cytokines. Recent work indicates that the NALP3-inflammasome can be activated by endogenous "danger signals" as well as compounds associated with pathogens (Kanneganti et al., 2006; Mariathasan et al., 2006, Martinon et al., 2006; Sutterwala et al., 2006). Here, we discuss new insights into the regulation of caspase-1 activity in the inflammatory response.Entities:
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Year: 2006 PMID： 16923387 DOI： 10.1016/j.cell.2006.08.002
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582