Literature DB >> 16923380

Avant garde fatty acid synthesis by trypanosomes.

John E Cronan1.   

Abstract

In this issue of Cell, Lee et al. (2006) report that the parasite Trypanosoma brucei synthesizes fatty acids in an unconventional way. T. brucei and two other trypanosomes use enzymes called elongases to synthesize myristate, a fourteen carbon (C14) fatty acid essential for pathogenesis. This is an unexpected finding as these enzymes were thought only to elongate already long (C16 or C18) acyl chains.

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Year:  2006        PMID： 16923380      PMCID： PMC7251752          DOI： 10.1016/j.cell.2006.08.001

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  9 in total

1.  Bacterial fatty acid biosynthesis: targets for antibacterial drug discovery.

Authors:  J W Campbell; J E Cronan
Journal:  Annu Rev Microbiol       Date:  2001       Impact factor: 15.500

2.  Function, attachment and synthesis of lipoic acid in Escherichia coli.

Authors:  John E Cronan; Xin Zhao; Yanfang Jiang
Journal:  Adv Microb Physiol       Date:  2005       Impact factor: 3.517

3.  Remarkable structural variation within fatty acid megasynthases.

Authors:  John E Cronan
Journal:  Nat Chem Biol       Date:  2006-05       Impact factor: 15.040

Review 4.  Lipid biology of Apicomplexa: perspectives for new drug targets, particularly for Toxoplasma gondii.

Authors:  Sabrina Sonda; Adrian B Hehl
Journal:  Trends Parasitol       Date:  2005-11-21

Review 5.  Fatty acid synthesis in African trypanosomes: a solution to the myristate mystery.

Authors:  K S Paul; D Jiang; Y S Morita; P T Englund
Journal:  Trends Parasitol       Date:  2001-08

6.  Fatty acid remodeling of glycosyl phosphatidylinositol anchors in Trypanosoma brucei: incorporation of fatty acids other than myristate.

Authors:  Y S Morita; P T Englund
Journal:  Mol Biochem Parasitol       Date:  2001-07       Impact factor: 1.759

7.  Specialized fatty acid synthesis in African trypanosomes: myristate for GPI anchors.

Authors:  Y S Morita; K S Paul; P T Englund
Journal:  Science       Date:  2000-04-07       Impact factor: 47.728

8.  Glycosyl-sn-1,2-dimyristylphosphatidylinositol is covalently linked to Trypanosoma brucei variant surface glycoprotein.

Authors:  M A Ferguson; M G Low; G A Cross
Journal:  J Biol Chem       Date:  1985-11-25       Impact factor: 5.157

9.  Toxicity of myristic acid analogs toward African trypanosomes.

Authors:  T L Doering; T Lu; K A Werbovetz; G W Gokel; G W Hart; J I Gordon; P T Englund
Journal:  Proc Natl Acad Sci U S A       Date:  1994-10-11       Impact factor: 11.205
  9 in total
  4 in total

Review 1.  Intermediary metabolism in protists: a sequence-based view of facultative anaerobic metabolism in evolutionarily diverse eukaryotes.

Authors:  Michael L Ginger; Lillian K Fritz-Laylin; Chandler Fulton; W Zacheus Cande; Scott C Dawson
Journal:  Protist       Date:  2010-10-30

2.  The Glycerol-3-Phosphate Acyltransferase TbGAT is Dispensable for Viability and the Synthesis of Glycerolipids in Trypanosoma brucei.

Authors:  Nipul Patel; Karim A Pirani; Tongtong Zhu; Melanie Cheung-See-Kit; Sungsu Lee; Daniel G Chen; Rachel Zufferey
Journal:  J Eukaryot Microbiol       Date:  2016-03-08       Impact factor: 3.346

3.  Bacterial fatty acid synthesis and its relationships with polyketide synthetic pathways.

Authors:  John E Cronan; Jacob Thomas
Journal:  Methods Enzymol       Date:  2009       Impact factor: 1.600

4.  The Trypanosoma brucei dihydroxyacetonephosphate acyltransferase TbDAT is dispensable for normal growth but important for synthesis of ether glycerophospholipids.

Authors:  Rachel Zufferey; Karim Pirani; Melanie Cheung-See-Kit; Sungsu Lee; Tyler A Williams; Daniel G Chen; Md Faruk Hossain
Journal:  PLoS One       Date:  2017-07-17       Impact factor: 3.240
  4 in total

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