Literature DB >> 1692298

Mapping the human amylase gene cluster on the proximal short arm of chromosome 1 using a highly informative (CA)n repeat.

N C Dracopoli1, M H Meisler.   

Abstract

The human amylase gene cluster includes a (CA)n repeat sequence immediately upstream of the gamma-actin pseudogene associated with the AMY2B gene. Analysis of this (CA)n repeat by PCR amplification of genomic DNA from the 40 families of the Centre d'Etude du Polymorphisme Humain (CEPH) reference panel revealed extensive polymorphism. A total of six alleles with (CA)n lengths of 16-21 repeats were found. The average heterozygosity for this polymorphism was 0.70. Multipoint linkage analysis showed that the amylase gene cluster is located distal to the nerve growth factor beta-subunit gene (NGFB) and is within 1 cM of the anonymous locus D1S10. The amylase (CA)n repeat provides a convenient marker for both the physical and the genetic maps of human chromosome 1p.

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Year:  1990        PMID： 1692298     DOI： 10.1016/0888-7543(90)90523-w

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  10 in total

Review 1.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

2.  Regional chromosomal assignment of human 3-beta-hydroxy-5-ene steroid dehydrogenase to 1p13.1 by non-isotopic in situ hybridisation.

Authors:  N Morrison; D A Nickson; M W McBride; U W Mueller; E Boyd; R G Sutcliffe
Journal:  Hum Genet       Date:  1991-06       Impact factor: 4.132

3.  Localization of a gene for autosomal dominant osteopetrosis (Albers-Schönberg disease) to chromosome 1p21.

Authors:  W Van Hul; J Bollerslev; J Gram; E Van Hul; W Wuyts; O Benichou; F Vanhoenacker; P J Willems
Journal:  Am J Hum Genet       Date:  1997-08       Impact factor: 11.025

4.  Use of short sequence repeat DNA polymorphisms after PCR amplification to detect the parental origin of the additional chromosome 21 in Down syndrome.

Authors:  M B Petersen; A A Schinzel; F Binkert; L Tranebjaerg; M Mikkelsen; F A Collins; E P Economou; S E Antonarakis
Journal:  Am J Hum Genet       Date:  1991-01       Impact factor: 11.025

Review 5.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

Review 6.  Genetic aspects of central hypothyroidism.

Authors:  R Collu
Journal:  J Endocrinol Invest       Date:  2000-02       Impact factor: 4.256

7.  Identification of chromosome 21 DNA polymorphisms for genetic studies in Alzheimer's disease and Down syndrome.

Authors:  G Van Camp; H Backhovens; M Cruts; A Wehnert; W Van Hul; P Stinissen; C Van Broeckhoven
Journal:  Hum Genet       Date:  1991-10       Impact factor: 4.132

8.  Enhanced PCR amplification of VNTR locus D1S80 using peptide nucleic acid (PNA).

Authors:  D B Demers; E T Curry; M Egholm; A C Sozer
Journal:  Nucleic Acids Res       Date:  1995-08-11       Impact factor: 16.971

9.  Analysis of 21 Stargardt's disease families confirms a major locus on chromosome 1p with evidence for non-allelic heterogeneity in a minority of cases.

Authors:  B H Weber; S Sander; C Kopp; D Walker; A Eckstein; B Wissinger; E Zrenner; T Grimm
Journal:  Br J Ophthalmol       Date:  1996-08       Impact factor: 4.638

10.  Pseudocyst or tumour? An amylase-producing leiomyosarcoma.

Authors:  T W Hennigan; M Collins; T C Naughton-Morgan; N A Theodorou
Journal:  J R Soc Med       Date:  1992-10       Impact factor: 18.000
  10 in total

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