PURPOSE: We sought to analyze the contralateral volumes of the temporal pole, posterior segment of the temporal lobe, amygdala, hippocampus, and parahippocampal gyrus in patients with temporal lobe epilepsy (TLE) due to histologically proven mesial temporal lobe sclerosis (MTLS), seizure free for >or=4 years of postsurgical follow-up. METHODS: Forty-six (23 male) TLE patients, operated on between 1996 and 2001, with histopathologic diagnosis of MTLS, and a postsurgical follow-up of >or=4 years, had their temporal lobe structures manually segmented, measured, and compared with those of 23 normal volunteers, paired as groups for sex, age, and handedness. RESULTS: The mean volumes of the contralateral temporal pole, hippocampus, and parahippocampal gyrus in TLE patients were significantly lower than those in controls. CONCLUSIONS: MRI volumetric data show that the damage in TLE due to MTS may be more widespread and bilateral, even in patients with unilateral TLE by clinical and neurophysiological criteria. Our results are relevant to the discussion of epileptogenic mechanisms in TLE.
PURPOSE: We sought to analyze the contralateral volumes of the temporal pole, posterior segment of the temporal lobe, amygdala, hippocampus, and parahippocampal gyrus in patients with temporal lobe epilepsy (TLE) due to histologically proven mesial temporal lobe sclerosis (MTLS), seizure free for >or=4 years of postsurgical follow-up. METHODS: Forty-six (23 male) TLEpatients, operated on between 1996 and 2001, with histopathologic diagnosis of MTLS, and a postsurgical follow-up of >or=4 years, had their temporal lobe structures manually segmented, measured, and compared with those of 23 normal volunteers, paired as groups for sex, age, and handedness. RESULTS: The mean volumes of the contralateral temporal pole, hippocampus, and parahippocampal gyrus in TLEpatients were significantly lower than those in controls. CONCLUSIONS: MRI volumetric data show that the damage in TLE due to MTS may be more widespread and bilateral, even in patients with unilateral TLE by clinical and neurophysiological criteria. Our results are relevant to the discussion of epileptogenic mechanisms in TLE.
Authors: Rodrigo Bainy Leal; Mark William Lopes; Douglas Affonso Formolo; Cristiane Ribeiro de Carvalho; Alexandre Ademar Hoeller; Alexandra Latini; Daniel Santos Sousa; Peter Wolf; Rui Daniel Prediger; Zuner Assis Bortolotto; Marcelo Neves Linhares; Kátia Lin; Roger Walz Journal: Mol Psychiatry Date: 2018-06-07 Impact factor: 15.992
Authors: P R B Diniz; T R Velasco; C E G Salmon; A C Sakamoto; J P Leite; A C Santos Journal: AJNR Am J Neuroradiol Date: 2011-09-01 Impact factor: 3.825
Authors: Victoria L Morgan; Baxter P Rogers; Hasan H Sonmezturk; John C Gore; Bassel Abou-Khalil Journal: Epilepsia Date: 2011-07-29 Impact factor: 5.864
Authors: Richard L Doty; Isabelle Tourbier; Jessica K Neff; Jonathan Silas; Bruce Turetsky; Paul Moberg; Taehoon Kim; John Pluta; Jaqueline French; Ashwini D Sharan; Michael J Sperling; Natasha Mirza; Anthony Risser; Gordon Baltuch; John A Detre Journal: J Neurol Date: 2018-05-16 Impact factor: 4.849
Authors: Joseph I Tracy; Karol Osipowicz; Philip Spechler; Ashwini Sharan; Christopher Skidmore; Gaelle Doucet; Michael R Sperling Journal: Hum Brain Mapp Date: 2012-09-15 Impact factor: 5.038
Authors: M E Ahmadi; D J Hagler; C R McDonald; E S Tecoma; V J Iragui; A M Dale; E Halgren Journal: AJNR Am J Neuroradiol Date: 2009-06-09 Impact factor: 3.825