Literature DB >> 16920176

Potent inhibition of human Hepatitis B virus replication by a host factor Vps4.

Pong Kian Chua1, Min-Hui Lin, Chiaho Shih.   

Abstract

Vps4 is a host factor known to be involved in cellular vacuolar protein sorting. We report here that HBV replication and secretion can be significantly inhibited by Vps4 dominant negative, ATPase-defective, mutants K173Q and E228Q. In contrast, wild-type Vps4 at low dose can inhibit HBV replication more effectively in human hepatoblastoma cell line HepG2, than in human hepatoma cell line Huh7. To our knowledge, this is the first demonstration of an anti-HBV potential of dominant negative mutants of a protein sorting host factor Vps4.

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Year:  2006        PMID： 16920176     DOI： 10.1016/j.virol.2006.07.018

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  33 in total

1.  Ubiquitin depletion and dominant-negative VPS4 inhibit rhabdovirus budding without affecting alphavirus budding.

Authors:  Gwen M Taylor; Phyllis I Hanson; Margaret Kielian
Journal:  J Virol       Date:  2007-10-03       Impact factor: 5.103

Review 2.  Molecular biology of hepatitis B virus infection.

Authors:  Christoph Seeger; William S Mason
Journal:  Virology       Date:  2015-03-07       Impact factor: 3.616

3.  The ubiquitin-proteasome system plays an important role during various stages of the coronavirus infection cycle.

Authors:  Matthijs Raaben; Clara C Posthuma; Monique H Verheije; Eddie G te Lintelo; Marjolein Kikkert; Jan W Drijfhout; Eric J Snijder; Peter J M Rottier; Cornelis A M de Haan
Journal:  J Virol       Date:  2010-05-19       Impact factor: 5.103

4.  Small Interfering RNA Screening for the Small GTPase Rab Proteins Identifies Rab5B as a Major Regulator of Hepatitis B Virus Production.

Authors:  Jun Inoue; Masashi Ninomiya; Teruyuki Umetsu; Takuya Nakamura; Takayuki Kogure; Eiji Kakazu; Tomoaki Iwata; Satoshi Takai; Akitoshi Sano; Mitsunori Fukuda; Koichi Watashi; Masanori Isogawa; Yasuhito Tanaka; Tooru Shimosegawa; Mark A McNiven; Atsushi Masamune
Journal:  J Virol       Date:  2019-07-17       Impact factor: 5.103

5.  Inhibition of HBV replication by VPS4B and its dominant negative mutant VPS4B-K180Q in vivo.

Authors:  Jianbo Xia; Weipeng Wang; Lei Li; Zhi Liu; Min Liu; Dongliang Yang
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2012-06-09

Review 6.  Hepatitis B and C virus hepatocarcinogenesis: lessons learned and future challenges.

Authors:  Michael J Bouchard; Sonia Navas-Martin
Journal:  Cancer Lett       Date:  2010-12-18       Impact factor: 8.679

Review 7.  Host factors involved in hepatitis B virus maturation, assembly, and egress.

Authors:  Reinhild Prange
Journal:  Med Microbiol Immunol       Date:  2012-09-11       Impact factor: 3.402

8.  The pre-S1 and antigenic loop infectivity determinants of the hepatitis B virus envelope proteins are functionally independent.

Authors:  Yann Le Duff; Matthieu Blanchet; Camille Sureau
Journal:  J Virol       Date:  2009-09-16       Impact factor: 5.103

9.  Hepatitis B virus maturation is sensitive to functional inhibition of ESCRT-III, Vps4, and gamma 2-adaptin.

Authors:  Carsten Lambert; Tatjana Döring; Reinhild Prange
Journal:  J Virol       Date:  2007-06-06       Impact factor: 5.103

10.  Involvement of host cellular multivesicular body functions in hepatitis B virus budding.

Authors:  Tokiko Watanabe; Ericka M Sorensen; Akira Naito; Meghan Schott; Seungtaek Kim; Paul Ahlquist
Journal:  Proc Natl Acad Sci U S A       Date:  2007-06-05       Impact factor: 11.205
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