Literature DB >> 16919606

Transplantation of multipotent astrocytic stem cells into a rat model of neonatal hypoxic-ischemic encephalopathy.

Tong Zheng1, Candace Rossignol, Avital Leibovici, Kevin J Anderson, Dennis A Steindler, Michael D Weiss.   

Abstract

Hypoxic-ischemic encephalopathy (HIE) in neonates results in long-term disabilities. Stem cell therapy may offer an attractive treatment for HIE. Multipotent astrocytic stem cells (MASCs) from mice transplanted into a rat model of hypoxia-ischemia (HI) survived the transplantation and showed signs of migration towards the injured cortex. Some MASCs around the injured cortex differentiated into neuronal and astrocytic phenotypes. MASCs transplanted into non-ischemic pups survived but retained their astrocytic phenotype. These data suggest that transplanted MASCs can survive and differentiate into neurons and astrocytes in the post-injury milieu of the neonatal brain injured by HI.

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Year:  2006        PMID： 16919606     DOI： 10.1016/j.brainres.2006.07.014

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  13 in total

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Authors:  Dennis A Steindler
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2.  Focal cerebral ischemia induces a multilineage cytogenic response from adult subventricular zone that is predominantly gliogenic.

Authors:  Lu Li; Kate M Harms; P Britten Ventura; Diane C Lagace; Amelia J Eisch; Lee Anna Cunningham
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Review 3.  Baby STEPS: a giant leap for cell therapy in neonatal brain injury.

Authors:  Cesar V Borlongan; Michael D Weiss
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Review 4.  The potential for cell-based therapy in perinatal brain injuries.

Authors:  Andre W Phillips; Michael V Johnston; Ali Fatemi
Journal:  Transl Stroke Res       Date:  2013-04       Impact factor: 6.829

5.  Transplantation of placenta-derived mesenchymal stem cells reduces hypoxic-ischemic brain damage in rats by ameliorating the inflammatory response.

Authors:  Hongfang Ding; Hui Zhang; Huifang Ding; Dong Li; Xinhao Yi; Xiaoxu Ma; Ruijuan Li; Mei Huang; Xiuli Ju
Journal:  Cell Mol Immunol       Date:  2015-12-28       Impact factor: 11.530

6.  Gelatinized copper-capillary alginate gel functions as an injectable tissue scaffolding system for stem cell transplants.

Authors:  Bradley Jay Willenberg; Tong Zheng; Fan-Wei Meng; Juan Carlos Meneses; Candace Rossignol; Christopher D Batich; Naohiro Terada; Dennis A Steindler; Michael D Weiss
Journal:  J Biomater Sci Polym Ed       Date:  2010-08-09       Impact factor: 3.682

7.  Neuroprotective effects of ginsenoside Rg1-induced neural stem cell transplantation on hypoxic-ischemic encephalopathy.

Authors:  Ying-Bo Li; Yan Wang; Ji-Ping Tang; Di Chen; Sha-Li Wang
Journal:  Neural Regen Res       Date:  2015-05       Impact factor: 5.135

8.  Mannitol facilitates neurotrophic factor up-regulation and behavioural recovery in neonatal hypoxic-ischaemic rats with human umbilical cord blood grafts.

Authors:  T Yasuhara; K Hara; M Maki; L Xu; G Yu; M M Ali; T Masuda; S J Yu; E K Bae; T Hayashi; N Matsukawa; Y Kaneko; N Kuzmin-Nichols; S Ellovitch; E L Cruz; S K Klasko; C D Sanberg; P R Sanberg; C V Borlongan
Journal:  J Cell Mol Med       Date:  2010-04       Impact factor: 5.310

9.  Neurotrophin-induced migration and neuronal differentiation of multipotent astrocytic stem cells in vitro.

Authors:  Martha Douglas-Escobar; Candace Rossignol; Dennis Steindler; Tong Zheng; Michael D Weiss
Journal:  PLoS One       Date:  2012-12-12       Impact factor: 3.240

10.  The olfactory bulb in newborn piglet is a reservoir of neural stem and progenitor cells.

Authors:  Lee J Martin; Alyssa Katzenelson; Raymond C Koehler; Qing Chang
Journal:  PLoS One       Date:  2013-11-21       Impact factor: 3.240
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