| Literature DB >> 16919456 |
Jinlong Jiang1, Myle Hoang, Jonathan R Young, Danny Chaung, Ronsar Eid, Cherilyn Turner, Peter Lin, Xinchun Tong, Junying Wang, Carina Tan, Scott Feighner, Oksana Palyha, Donna L Hreniuk, Jie Pan, Andreas W Sailer, Douglas J MacNeil, Andrew Howard, Lauren Shearman, Sloan Stribling, Ramon Camacho, Alison Strack, Lex H T Van der Ploeg, Mark T Goulet, Robert J DeVita.
Abstract
A series of 2-aminoquinoline compounds was prepared and evaluated in MCH1R binding and functional antagonist assays. Small dialkyl, methylalkyl, methylcycloalkyl, and cyclic amines were tolerated at the quinoline 2-position. The in vivo efficacy of compound 12 was explored and compared to that of a related inactive analog to determine their effects on food intake and body weight in rodents.Entities:
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Year: 2006 PMID： 16919456 DOI： 10.1016/j.bmcl.2006.08.006
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823