Literature DB >> 16919451

A homology model of SERT based on the LeuT(Aa) template.

Aina Westrheim Ravna1, Malgorzata Jaronczyk, Ingebrigt Sylte.   

Abstract

A human serotonin transporter (SERT) model has been constructed based on the crystal structure of the bacterial homologue of Na(+)/Cl(-)-dependent neurotransmitter transporters from Aquifex aeolicus (LeuT(Aa)). Amino acids in the ligand binding area predicted by ICM pocket finder included Tyr95, Ala96, Asp98, Gly100 (transmembrane helix (TMH) 1), Ala169, Ile172, Ala173, Tyr176 (TMH3), Phe335, Ser336, Gly338, Phe341, Val343 (TMH6), Thr439, Ala441, and Gly442 (TMH8). The present model is an updated working tool for experimental studies on SERT.

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Year:  2006        PMID： 16919451     DOI： 10.1016/j.bmcl.2006.08.028

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

Review 1.  Monoamine transporter structure, function, dynamics, and drug discovery: a computational perspective.

Authors:  Sankar Manepalli; Christopher K Surratt; Jeffry D Madura; Tammy L Nolan
Journal:  AAPS J       Date:  2012-08-24       Impact factor: 4.009

Review 2.  Monoamine transporters: vulnerable and vital doorkeepers.

Authors:  Zhicheng Lin; Juan J Canales; Thröstur Björgvinsson; Morgane Thomsen; Hong Qu; Qing-Rong Liu; Gonzalo E Torres; S Barak Caine
Journal:  Prog Mol Biol Transl Sci       Date:  2011       Impact factor: 3.622

3.  Structural analysis of the extracellular entrance to the serotonin transporter permeation pathway.

Authors:  Melissa I Torres-Altoro; Charles P Kuntz; David E Nichols; Eric L Barker
Journal:  J Biol Chem       Date:  2010-03-19       Impact factor: 5.157

4.  Structure and localisation of drug binding sites on neurotransmitter transporters.

Authors:  Aina W Ravna; Ingebrigt Sylte; Svein G Dahl
Journal:  J Mol Model       Date:  2009-02-24       Impact factor: 1.810

5.  Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies.

Authors:  Kristian W Kaufmann; Eric S Dawson; L Keith Henry; Julie R Field; Randy D Blakely; Jens Meiler
Journal:  Proteins       Date:  2009-02-15

6.  Helix XI contributes to the entrance of the serotonin transporter permeation pathway.

Authors:  Melissa I Torres-Altoro; Kellie J White; Gustavo J Rodríguez; David E Nichols; Eric L Barker
Journal:  Protein Sci       Date:  2008-07-15       Impact factor: 6.725

7.  Substrate binding and formation of an occluded state in the leucine transporter.

Authors:  Leyla Celik; Birgit Schiøtt; Emad Tajkhorshid
Journal:  Biophys J       Date:  2007-11-16       Impact factor: 4.033

8.  Chloride binding site of neurotransmitter sodium symporters.

Authors:  Adriana K Kantcheva; Matthias Quick; Lei Shi; Anne-Marie Lund Winther; Sebastian Stolzenberg; Harel Weinstein; Jonathan A Javitch; Poul Nissen
Journal:  Proc Natl Acad Sci U S A       Date:  2013-05-02       Impact factor: 11.205

9.  Molecular model of the outward facing state of the human P-glycoprotein (ABCB1), and comparison to a model of the human MRP5 (ABCC5).

Authors:  Aina W Ravna; Ingebrigt Sylte; Georg Sager
Journal:  Theor Biol Med Model       Date:  2007-09-06       Impact factor: 2.432

10.  Focus on Human Monoamine Transporter Selectivity. New Human DAT and NET Models, Experimental Validation, and SERT Affinity Exploration.

Authors:  Gabriella Ortore; Elisabetta Orlandini; Laura Betti; Gino Giannaccini; Maria Rosa Mazzoni; Caterina Camodeca; Susanna Nencetti
Journal:  ACS Chem Neurosci       Date:  2020-10-13       Impact factor: 4.418
  10 in total

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