| Literature DB >> 16919274 |
Patrícia Oliveira Prada1, José Rodrigo Pauli, Eduardo Rochete Ropelle, Henrique Gottardello Zecchin, José Barreto Campello Carvalheira, Lício Augusto Velloso, Mario José Abdalla Saad.
Abstract
A high-fat diet (HFD) is associated with reduced glucose uptake in muscle, but not in adipose tissue. In the present study, we investigated whether a HFD can modulate glucose uptake in adipose tissue by increasing signal transduction through the CAP/Cbl pathway, independently of the PI3-K/Akt pathway. Our results suggest that, in HFD, the differential regulation of insulin-induced glucose uptake between skeletal muscle and adipose tissue may, in part, be a consequence of the CAP/Cbl/C3G pathway, since the expression of CAP and Cbl, and also the activation of this pathway were increased in adipose tissue but not in muscle.Entities:
Mesh：
Substances：
Year: 2006 PMID： 16919274 DOI： 10.1016/j.febslet.2006.08.004
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124