| Literature DB >> 16918496 |
María del Carmen Maeso Fortuny1, Buenaventura Brito Díaz, Antonio Cabrera de León.
Abstract
Obesity is a state of leptin resistance in which the membrane leptin receptor and the JAK-STAT pathway are blocked. This leads to increased intracellular concentrations of lipid metabolites, increased non-oxidative metabolism by adipocytes, and stimulation of the cell estrogen cycle. These factors are potentially oncogenic via the shared mitogen-activated protein kinase (MAPK), mitogen/extracellular signal-regulated kinase (MEK) and extracellular signal-regulated kinase (ERK) cellular pathways.Entities:
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Year: 2006 PMID： 16918496 DOI： 10.2174/138955706777934973
Source DB: PubMed Journal: Mini Rev Med Chem ISSN： 1389-5575 Impact factor: 3.862