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Literature DB >> 16918494

Potential for discovery of neuroprotective factors in serum and tissue from hibernating species.

Abstract

Hibernation is a unique phenotype displayed by a phylogenetically diverse group of organisms including several species of mammals and one species of primate. Here we review evidence for blood and tissue borne signaling molecules in hibernating animals, achievements in isolating and characterizing these molecules, and potential medicinal applications.

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Year: 2006 PMID： 16918494 PMCID： PMC4454377 DOI： 10.2174/138955706777934964

Source DB: PubMed Journal: Mini Rev Med Chem ISSN： 1389-5575 Impact factor: 3.862

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References

136 in total

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Potential for discovery of neuroprotective factors in serum and tissue from hibernating species.

Review 1. Comparative analysis of cell replacement in hibernators.

2. Downregulation of sodium channels during anoxia: a putative survival strategy of turtle brain.

Review 3. Neurodegeneration and plasticity.

4. The effect of some peptides from the hibernating brain on Ca2+ current in cardiac cells and on the activity of septal neurons.

5. Seasonal variations of DNA synthesis in intestinal epithelial cells of hibernating animals--I. DNA synthesis in intestinal epithelial cells of ground squirrel (Citellus undulatus) during deep hibernation.

6. Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor alpha.

Review 7. Cold ischemic organ preservation: lessons from natural systems.

8. Role for adenosine in channel arrest in the anoxic turtle brain.

9. Mammalian hibernation: lessons for organ preparation?

10. Physiology: hibernation in a tropical primate.