Literature DB >> 16918462

Design and synthesis of phosphonodifluoromethyl phenylalanine (F2Pmp): a useful phosphotyrosyl mimetic.

Terrence R Burke1.   

Abstract

Hydrolytically-stable phosphotyrosyl (pTyr) mimetics can be useful tools for the study of cellular signal transduction processes. Among pTyr mimetics reported to date, phosphono(diflouromethyl)phenylalanine (F(2)Pmp) has shown particular utility when dealing with protein-tyrosine phosphatases (PTPs). The current overview presents the development of F(2)Pmp and a summary of approaches toward its synthesis and use.

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Year:  2006        PMID： 16918462     DOI： 10.2174/156802606777951091

Source DB:  PubMed          Journal:  Curr Top Med Chem        ISSN： 1568-0266            Impact factor:   3.295


  5 in total

1.  A convenient synthesis of the C-1-phosphonate analogue of UDP-GlcNAc and its evaluation as an inhibitor of O-linked GlcNAc transferase (OGT).

Authors:  Jan Hajduch; Ghilsoo Nam; Eun Ju Kim; Roland Fröhlich; John A Hanover; Kenneth L Kirk
Journal:  Carbohydr Res       Date:  2007-11-01       Impact factor: 2.104

Review 2.  Advances in Fmoc solid-phase peptide synthesis.

Authors:  Raymond Behrendt; Peter White; John Offer
Journal:  J Pept Sci       Date:  2016-01       Impact factor: 1.905

3.  Targeting Oncogenic Src Homology 2 Domain-Containing Phosphatase 2 (SHP2) by Inhibiting Its Protein-Protein Interactions.

Authors:  Sara Bobone; Luca Pannone; Barbara Biondi; Maja Solman; Elisabetta Flex; Viviana Claudia Canale; Paolo Calligari; Chiara De Faveri; Tommaso Gandini; Andrea Quercioli; Giuseppe Torini; Martina Venditti; Antonella Lauri; Giulia Fasano; Jelmer Hoeksma; Valerio Santucci; Giada Cattani; Alessio Bocedi; Giovanna Carpentieri; Valentina Tirelli; Massimo Sanchez; Cristina Peggion; Fernando Formaggio; Jeroen den Hertog; Simone Martinelli; Gianfranco Bocchinfuso; Marco Tartaglia; Lorenzo Stella
Journal:  J Med Chem       Date:  2021-10-29       Impact factor: 7.446

4.  Pentafluorophosphato-Phenylalanines: Amphiphilic Phosphotyrosine Mimetics Displaying Fluorine-Specific Protein Interactions.

Authors:  Matteo Accorsi; Markus Tiemann; Leon Wehrhan; Lauren M Finn; Ruben Cruz; Max Rautenberg; Franziska Emmerling; Joachim Heberle; Bettina G Keller; Jörg Rademann
Journal:  Angew Chem Int Ed Engl       Date:  2022-04-25       Impact factor: 16.823

Review 5.  Application of cyclic phosphonamide reagents in the total synthesis of natural products and biologically active molecules.

Authors:  Thilo Focken; Stephen Hanessian
Journal:  Beilstein J Org Chem       Date:  2014-08-13       Impact factor: 2.883
  5 in total

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