Literature DB >> 16918129

Effect of resveratrol on proliferation and telomerase activity of human colon cancer cells in vitro.

M P Fuggetta1, G Lanzilli, M Tricarico, A Cottarelli, R Falchetti, G Ravagnan, E Bonmassar.   

Abstract

A number of studies performed in our laboratory and elsewhere, showed that resveratrol is able to prevent carcinogenesis and to impair tumor growth and progression. In order to provide additional information on the pleiotropic effects of resveratrol on malignant cells, the present study was performed to test the in vitro influence of the compound on the growth and TLMA of HT-29 and WiDr human colon cancer cell lines. The results confirmed that resveratrol has a direct, dose dependent, inhibitory effect on cell proliferation in both lines. In addition, for the first time, relatively high concentrations of this compound were found to be able to substantially down-regulate telomerase activity. These preliminary results further support the potential role of resveratrol in chemoprevention/chemotherapy of human colon tumor cells and provide the rational basis for novel strategies in cancer control.

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Year:  2006        PMID： 16918129

Source DB:  PubMed          Journal:  J Exp Clin Cancer Res        ISSN： 0392-9078


  30 in total

Review 1.  Colorectal cancer: chemopreventive role of curcumin and resveratrol.

Authors:  Vaishali B Patel; Sabeena Misra; Bhaumik B Patel; Adhip P N Majumdar
Journal:  Nutr Cancer       Date:  2010       Impact factor: 2.900

2.  Natural products and colon cancer: current status and future prospects.

Authors:  Subapriya Rajamanickam; Rajesh Agarwal
Journal:  Drug Dev Res       Date:  2008-11-01       Impact factor: 4.360

Review 3.  Evasion of anti-growth signaling: A key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds.

Authors:  A R M Ruhul Amin; Phillip A Karpowicz; Thomas E Carey; Jack Arbiser; Rita Nahta; Zhuo G Chen; Jin-Tang Dong; Omer Kucuk; Gazala N Khan; Gloria S Huang; Shijun Mi; Ho-Young Lee; Joerg Reichrath; Kanya Honoki; Alexandros G Georgakilas; Amedeo Amedei; Amr Amin; Bill Helferich; Chandra S Boosani; Maria Rosa Ciriolo; Sophie Chen; Sulma I Mohammed; Asfar S Azmi; W Nicol Keith; Dipita Bhakta; Dorota Halicka; Elena Niccolai; Hiromasa Fujii; Katia Aquilano; S Salman Ashraf; Somaira Nowsheen; Xujuan Yang; Alan Bilsland; Dong M Shin
Journal:  Semin Cancer Biol       Date:  2015-03-06       Impact factor: 15.707

Review 4.  Sustained proliferation in cancer: Mechanisms and novel therapeutic targets.

Authors:  Mark A Feitelson; Alla Arzumanyan; Rob J Kulathinal; Stacy W Blain; Randall F Holcombe; Jamal Mahajna; Maria Marino; Maria L Martinez-Chantar; Roman Nawroth; Isidro Sanchez-Garcia; Dipali Sharma; Neeraj K Saxena; Neetu Singh; Panagiotis J Vlachostergios; Shanchun Guo; Kanya Honoki; Hiromasa Fujii; Alexandros G Georgakilas; Alan Bilsland; Amedeo Amedei; Elena Niccolai; Amr Amin; S Salman Ashraf; Chandra S Boosani; Gunjan Guha; Maria Rosa Ciriolo; Katia Aquilano; Sophie Chen; Sulma I Mohammed; Asfar S Azmi; Dipita Bhakta; Dorota Halicka; W Nicol Keith; Somaira Nowsheen
Journal:  Semin Cancer Biol       Date:  2015-04-17       Impact factor: 15.707

5.  Anti-inflammatory effect of resveratrol and polydatin by in vitro IL-17 modulation.

Authors:  Giulia Lanzilli; Andrea Cottarelli; Giuseppe Nicotera; Serena Guida; Giampiero Ravagnan; Maria Pia Fuggetta
Journal:  Inflammation       Date:  2012-02       Impact factor: 4.092

Review 6.  Cancer prevention and therapy through the modulation of the tumor microenvironment.

Authors:  Stephanie C Casey; Amedeo Amedei; Katia Aquilano; Asfar S Azmi; Fabian Benencia; Dipita Bhakta; Alan E Bilsland; Chandra S Boosani; Sophie Chen; Maria Rosa Ciriolo; Sarah Crawford; Hiromasa Fujii; Alexandros G Georgakilas; Gunjan Guha; Dorota Halicka; William G Helferich; Petr Heneberg; Kanya Honoki; W Nicol Keith; Sid P Kerkar; Sulma I Mohammed; Elena Niccolai; Somaira Nowsheen; H P Vasantha Rupasinghe; Abbas Samadi; Neetu Singh; Wamidh H Talib; Vasundara Venkateswaran; Richard L Whelan; Xujuan Yang; Dean W Felsher
Journal:  Semin Cancer Biol       Date:  2015-04-10       Impact factor: 15.707

7.  Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients.

Authors:  Ketan R Patel; Victoria A Brown; Donald J L Jones; Robert G Britton; David Hemingway; Andrew S Miller; Kevin P West; Tristan D Booth; Marjorie Perloff; James A Crowell; Dean E Brenner; William P Steward; Andreas J Gescher; Karen Brown
Journal:  Cancer Res       Date:  2010-09-14       Impact factor: 12.701

8.  Effects of various agents on DNA fragmentation and telomerase enzyme activities in adenocarcinoma cell lines.

Authors:  Didem Turgut Cosan; Ahu Soyocak; Ayse Basaran; Irfan Degirmenci; Hasan Veysi Gunes; Fezan Mutlu Sahin
Journal:  Mol Biol Rep       Date:  2010-11-20       Impact factor: 2.316

Review 9.  Resveratrol: a review of preclinical studies for human cancer prevention.

Authors:  Mohammad Athar; Jung Ho Back; Xiuwei Tang; Kwang Ho Kim; Levy Kopelovich; David R Bickers; Arianna L Kim
Journal:  Toxicol Appl Pharmacol       Date:  2007-01-03       Impact factor: 4.219

10.  Resveratrol prevents tumorigenesis in mouse model of Kras activated sporadic colorectal cancer by suppressing oncogenic Kras expression.

Authors:  Shakir M Saud; Weidong Li; Nicole L Morris; Matthias S Matter; Nancy H Colburn; Young S Kim; Matthew R Young
Journal:  Carcinogenesis       Date:  2014-10-03       Impact factor: 4.944
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