Literature DB >> 16917781

Murine polyomavirus-like particles induce maturation of bone marrow-derived dendritic cells and proliferation of T cells.

Thomas Bickert1, Gisela Wohlleben, Marc Brinkman, Claudia M Trujillo-Vargas, Claus Ruehland, Christian O A Reiser, Juergen Hess, Klaus J Erb.   

Abstract

We analysed the effects of murine polyomavirus-like particles (PLPs) on bone marrow-derived dendritic cells (BMDCs) and T cells in vitro. BMDCs activated with PLPs up-regulated CD40, CD80, CD86 and major histocompatibility complex (MHC) class II surface markers and produced proinflammatory cytokines. Chimeric PLPs [expressing the ovalbumin (OVA)-peptides OVA(257-264) or OVA(323-339)], but not wildtype PLPs, activated OVA-specific CD8 T cells and OVA-specific CD4 T cells, respectively, indicating both MHC class I and II presentation of the peptides by antigen-presenting cells. Our results suggest that PLPs may be used as vaccine adjuvants priming dendritic cells to induce potent T cell responses.

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Year:  2006        PMID： 16917781     DOI： 10.1007/s00430-006-0026-x

Source DB:  PubMed          Journal:  Med Microbiol Immunol        ISSN： 0300-8584            Impact factor:   3.402


  29 in total

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Journal:  J Immunol       Date:  2000-02-15       Impact factor: 5.422

2.  In vivo, dendritic cells can cross-present virus-like particles using an endosome-to-cytosol pathway.

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3.  An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow.

Authors:  M B Lutz; N Kukutsch; A L Ogilvie; S Rössner; F Koch; N Romani; G Schuler
Journal:  J Immunol Methods       Date:  1999-02-01       Impact factor: 2.303

Review 4.  The ubiquitin-proteasome system.

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Journal:  J Biosci       Date:  2006-03       Impact factor: 1.826

5.  Polyomavirus EGFP-pseudocapsids: analysis of model particles for introduction of proteins and peptides into mammalian cells.

Authors:  E Boura; D Liebl; R Spísek; J Fric; M Marek; J Stokrová; V Holán; J Forstová
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6.  Recombinant parvovirus-like particles as an antigen carrier: a novel nonreplicative exogenous antigen to elicit protective antiviral cytotoxic T cells.

Authors:  C Sedlik; M Saron; J Sarraseca; I Casal; C Leclerc
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7.  Chimeric papillomavirus virus-like particles elicit antitumor immunity against the E7 oncoprotein in an HPV16 tumor model.

Authors:  H L Greenstone; J D Nieland; K E de Visser; M L De Bruijn; R Kirnbauer; R B Roden; D R Lowy; W M Kast; J T Schiller
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Authors:  P Lenz; P M Day; Y Y Pang; S A Frye; P N Jensen; D R Lowy; J T Schiller
Journal:  J Immunol       Date:  2001-05-01       Impact factor: 5.422

9.  Vaccinations with T-helper type 1 directing adjuvants have different suppressive effects on the development of allergen-induced T-helper type 2 responses.

Authors:  C M Trujillo-Vargas; K D Mayer; T Bickert; A Palmetshofer; S Grunewald; J R Ramirez-Pineda; T Polte; G Hansen; G Wohlleben; K J Erb
Journal:  Clin Exp Allergy       Date:  2005-08       Impact factor: 5.018

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Authors:  Andrea Abbing; Ulrich K Blaschke; Swen Grein; Michael Kretschmar; Christoph M B Stark; Michael J W Thies; Jürgen Walter; Martina Weigand; Diemuth C Woith; Jürgen Hess; Christian O A Reiser
Journal:  J Biol Chem       Date:  2004-04-21       Impact factor: 5.157
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  3 in total

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Journal:  Drug Deliv Transl Res       Date:  2014-06       Impact factor: 4.617

2.  Alginate Particles with Ovalbumin (OVA) Peptide Can Serve as a Carrier and Adjuvant for Immune Therapy in B16-OVA Cancer Model.

Authors:  Longbao Zhu; Fei Ge; Liangjun Yang; Wanzhen Li; Shenghua Wei; Yugui Tao; Guocheng Du
Journal:  Med Sci Monit Basic Res       Date:  2017-04-28

3.  Advanced antigen delivery of murine survivin: chimeric virus-like particles in cancer vaccine research.

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Journal:  Int J Biomed Sci       Date:  2007-09
  3 in total

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