Literature DB >> 16917012

Role of P glycoprotein in absorption of novel antimalarial drugs.

Andrew Crowe1, Kenneth F Ilett, Harin A Karunajeewa, Kevin T Batty, Timothy M E Davis.   

Abstract

Bidirectional transport of four novel antimalarial compounds was determined using Caco-2 cell monolayers. P glycoprotein-mediated efflux was greatest for pyronaridine (5 to 20 microM) and low for naphthoquine (5 microM). With 20 microM naphthoquine, net efflux was blocked, suggesting saturation of the transporter. Piperaquine and dihydroartemisinin were not transported by the system.

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Year:  2006        PMID： 16917012      PMCID： PMC1610088          DOI： 10.1128/AAC.00708-06

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

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Authors:  Timothy M E Davis; Te-Yu Hung; Ing-Kye Sim; Harin A Karunajeewa; Kenneth F Ilett
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7.  In vitro and in situ absorption of SDZ-RAD using a human intestinal cell line (Caco-2) and a single pass perfusion model in rats: comparison with rapamycin.

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