| Literature DB >> 16916584 |
Alessandro Serretti1, Ioannis Liappas, Laura Mandelli, Diego Albani, Gianluigi Forloni, Petros Malitas, Christina Piperi, Aikaterini Zisaki, Elias O Tzavellas, Zeta Papadopoulou-Daifoti, Francesca Prato, Sara Batelli, Marzia Pesaresi, Anastasios Kalofoutis.
Abstract
Genetic factors may influence the liability to treatment outcome and medical complications in alcoholism. In the present study we investigated the IL-1A rs1800587, IL-1B rs3087258, TNF-alpha rs1799724 and the HTTLPR variants in a sample of 64 alcohol dependents and 47 relatives versus a set of clinical parameters and outcome measures. Alcohol dependents had a less favorable clinical profile compared to relatives (higher cholesterol, triglycerides, glucose, glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, gamma-glutamyltransferase). After detoxification, all clinical indexes improved and hepatic enzyme levels were similar in alcohol dependents and relatives, except for the GGT that remained significantly higher in alcohol dependents. Alcoholic depressive and anxiety scores were significantly reduced after detoxification. IL-1A, IL-1B, TNF-alpha and HTTLPR variants were not associated with any baseline clinical index or change after detoxification. In our sample IL-1A, IL-1B, TNF-alpha and HTTLPR do not appear as liability factors for alcohol toxicity or detoxification outcome, however the small sample size may influence the observed results.Entities:
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Year: 2006 PMID： 16916584 DOI： 10.1016/j.neulet.2006.07.003
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046