Literature DB >> 16916513

Regulation of the rat brain Na+ -driven Cl-/HCO3 - exchanger involves protein kinase A and a multiprotein signaling complex.

Yong-Sun Lee1, Yi-Bing Ouyang, Rona G Giffard.   

Abstract

The Na(+)-driven Cl(-)/HCO(3)(-) exchanger (NCBE) plays an important role in the regulation of intracellular pH (pH(i)). We previously identified two variants of NCBE from rat brain of which the variant with a carboxyterminal PSD-95/Dlg/ZO-1 (PDZ) motif (rb2NCBE) colocalized with the actin cytoskeleton. Increased rb2NCBE activity by PKA inhibition and reduction by forskolin and cAMP agonist suggest PKA regulation of NCBE. Disruption of actin filaments also decreased rb2NCBE activity. EBP50 and FLAG-rb2NCBE were reciprocally co-immunoprecipitated from rb2NCBE transfected cells. It is concluded that NCBE activity is inhibited by PKA and depends on the integrity of the actin cytoskeleton within a multiprotein complex at the plasma membrane.

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Year:  2006        PMID： 16916513     DOI： 10.1016/j.febslet.2006.07.075

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

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Review 7.  Regulators of Slc4 bicarbonate transporter activity.

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8.  Structure and Function of SLC4 Family [Formula: see text] Transporters.

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9.  Cloning and functional characterization of novel variants and tissue-specific expression of alternative amino and carboxyl termini of products of slc4a10.

Authors:  Ying Liu; Deng-Ke Wang; De-Zhi Jiang; Xue Qin; Zhang-Dong Xie; Qing K Wang; Mugen Liu; Li-Ming Chen
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  9 in total

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