Literature DB >> 16915821

Biosynthesis of 2-deoxystreptamine-containing antibiotics in Streptoalloteichus hindustanus JCM 3268: characterization of 2-deoxy-scyllo-inosose synthase.

Toshifumi Hirayama1, Hideyuki Tamegai, Fumitaka Kudo, Kazumasa Kojima, Katsumi Kakinuma, Tadashi Eguchi.   

Abstract

A part of the new biosynthetic gene cluster for 2-deoxystreptamine-containing antibiotics was identified from Streptoalloteichus hindustanus. The alloH gene in the gene cluster was deduced to encode 2-deoxy-scyllo-inosose synthase and the expressed protein AlloH was confirmed to have this enzyme activity. Furthermore, biochemical properties of AlloH were studied.

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Year:  2006        PMID： 16915821     DOI： 10.1038/ja.2006.51

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  5 in total

1.  C3'-Deoxygenation of Paromamine Catalyzed by a Radical S-Adenosylmethionine Enzyme: Characterization of the Enzyme AprD4 and Its Reductase Partner AprD3.

Authors:  Hak Joong Kim; Jake LeVieux; Yu-Cheng Yeh; Hung-Wen Liu
Journal:  Angew Chem Int Ed Engl       Date:  2016-02-16       Impact factor: 15.336

Review 2.  Comparison of Antibiotic Resistance Mechanisms in Antibiotic-Producing and Pathogenic Bacteria.

Authors:  Hiroshi Ogawara
Journal:  Molecules       Date:  2019-09-21       Impact factor: 4.411

3.  Substrate specificity of radical S-adenosyl-l-methionine dehydratase AprD4 and its partner reductase AprD3 in the C3'-deoxygenation of aminoglycoside antibiotics.

Authors:  Fumitaka Kudo; Takahiro Tokumitsu; Tadashi Eguchi
Journal:  J Antibiot (Tokyo)       Date:  2016-09-07       Impact factor: 2.649

Review 4.  Comparison of Strategies to Overcome Drug Resistance: Learning from Various Kingdoms.

Authors:  Hiroshi Ogawara
Journal:  Molecules       Date:  2018-06-18       Impact factor: 4.411

5.  Enhanced Biosynthesis of 2-Deoxy-scyllo-inosose in Metabolically Engineered Bacillus subtilis Recombinants.

Authors:  Joo Hyun Lim; Hyun Ha Hwang; Na Joon Lee; Jae Woo Lee; Eun Gyo Seo; Hye Bin Son; Hye Ji Kim; Yeo Joon Yoon; Je Won Park
Journal:  Front Microbiol       Date:  2018-09-27       Impact factor: 5.640
  5 in total

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