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Literature DB >> 16915819

Hypocrellin D, a cytotoxic fungal pigment from fruiting bodies of the ascomycete Shiraia bambusicola.

Li-Zhen Fang¹, Chen Qing, Hong-Jun Shao, Yi-Dong Yang, Ze-Jun Dong, Fei Wang, Wei Zhao, Wan-Qiu Yang, Ji-Kai Liu.

Abstract

A fungal pigment, hypocrellin D (1), together with three known perylenequinone derivatives hypocrellin A (2), B (3) and C (4), was isolated from the fruiting bodies of Shiraia bambusicola. Its structure was elucidated on the basis of spectral data including 2D NMR experiments. Hypocrellin D (1) significantly inhibited the growth of tumor cell lines Bel-7721, A-549 and Anip-973 with IC50 values of 1.8, 8.8, 38.4 microg/ml, respectively.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2006 PMID： 16915819 DOI： 10.1038/ja.2006.49

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Cited

10 in total

1. Selective oxidation of 8,8'-hydroxylated binaphthols to bis-spironaphthalenones or binaphtho-para- and binaphtho-ortho-quinones.

Authors: Erin E Podlesny; Patrick J Carroll; Marisa C Kozlowski
Journal: Org Lett Date: 2012-08-31 Impact factor: 6.005

2. A recyclable and light-triggered nanofibrous membrane against the emerging fungal pathogen Candida auris.

Authors: Xinyao Liu; Chuan Guo; Kaiwen Zhuang; Wei Chen; Muqiu Zhang; Yalin Dai; Lin Tan; Yuping Ran
Journal: PLoS Pathog Date: 2022-05-25 Impact factor: 7.464

3. Perylenequinones: Isolation, Synthesis, and Biological Activity.

Authors: Carol A Mulrooey; Erin M O'Brien; Barbara J Morgan; Marisa C Kozlowski
Journal: European J Org Chem Date: 2012-07-01

Review 4. Fungal Pigments and Their Prospects in Different Industries.

Authors: Ajay C Lagashetti; Laurent Dufossé; Sanjay K Singh; Paras N Singh
Journal: Microorganisms Date: 2019-11-22

5. Structural Diversity of Perylenequinones Is Driven by Their Redox Behavior.

Authors: Zeinab Y Al Subeh; Amy L Waldbusser; Huzefa A Raja; Cedric J Pearce; Kin Lok Ho; Michael J Hall; Michael R Probert; Nicholas H Oberlies; Shabnam Hematian
Journal: J Org Chem Date: 2022-01-25 Impact factor: 4.198

Review 6. Fungal perylenequinones.

Authors: Afra Khiralla; Aisha Ohag Mohammed; Sakina Yagi
Journal: Mycol Prog Date: 2022-04-04 Impact factor: 2.538

Hypocrellin D, a cytotoxic fungal pigment from fruiting bodies of the ascomycete Shiraia bambusicola.

1. Selective oxidation of 8,8'-hydroxylated binaphthols to bis-spironaphthalenones or binaphtho-para- and binaphtho-ortho-quinones.

2. A recyclable and light-triggered nanofibrous membrane against the emerging fungal pathogen Candida auris.

3. Perylenequinones: Isolation, Synthesis, and Biological Activity.

Review 4. Fungal Pigments and Their Prospects in Different Industries.

5. Structural Diversity of Perylenequinones Is Driven by Their Redox Behavior.

Review 6. Fungal perylenequinones.

7. Active Components of Fungus Shiraia bambusiscola Can Specifically Induce BGC823 Gastric Cancer Cell Apoptosis.

8. Enhanced hypocrellin production via coexpression of alpha-amylase and hemoglobin genes in Shiraia bambusicola.

9. Enhanced hypocrellin production of Shiraia sp. SUPER-H168 by overexpression of alpha-amylase gene.

Review 10. Anticancer and antifungal compounds from Aspergillus, Penicillium and other filamentous fungi.