Literature DB >> 16914854

Pathways to the discovery of the Abeta amyloid of Alzheimer's disease.

Colin L Masters1, Konrad Beyreuther.   

Abstract

Many participants played a role in discovering the composition and sequence of the Abeta amyloid of Alzheimer's disease. This sequence enabled the cloning of the amyloid precursor protein (APP), which elucidated its proteolytic origin from the membrane of neurons. The proteolytic enzymes which process APP and the Abeta fragment itself are now the prime validated drug targets for therapeutic intervention.

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Year:  2006        PMID： 16914854     DOI： 10.3233/jad-2006-9s318

Source DB:  PubMed          Journal:  J Alzheimers Dis        ISSN： 1387-2877            Impact factor:   4.472


  11 in total

Review 1.  The nature of amyloid-like glucagon fibrils.

Authors:  Jesper Søndergaard Pedersen
Journal:  J Diabetes Sci Technol       Date:  2010-11-01

2.  Aβ Plaques.

Authors:  Lary C Walker
Journal:  Free Neuropathol       Date:  2020-10-30

Review 3.  Alzheimer 100--highlights in the history of Alzheimer research.

Authors:  K A Jellinger
Journal:  J Neural Transm (Vienna)       Date:  2006-10-13       Impact factor: 3.575

4.  A History of Senile Plaques: From Alzheimer to Amyloid Imaging.

Authors:  Thomas G Beach
Journal:  J Neuropathol Exp Neurol       Date:  2022-05-20       Impact factor: 3.148

Review 5.  Molecular signaling pathway targeted therapeutic potential of thymoquinone in Alzheimer's disease.

Authors:  Fabiha Zaheen Khan; Md Shaki Mostaid; Mohd Nazmul Hasan Apu
Journal:  Heliyon       Date:  2022-07-05

Review 6.  Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease.

Authors:  Hyoung-Gon Lee; Gemma Casadesus; Xiongwei Zhu; Rudy J Castellani; Andrew McShea; George Perry; Robert B Petersen; Vladan Bajic; Mark A Smith
Journal:  Neurochem Int       Date:  2008-12-09       Impact factor: 3.921

Review 7.  Biomarkers for early diagnosis of Alzheimer disease: 'ALZheimer ASsociated gene'--a new blood biomarker?

Authors:  Kurt A Jellinger; Bernd Janetzky; Johannes Attems; Elisabeth Kienzl
Journal:  J Cell Mol Med       Date:  2008-03-19       Impact factor: 5.310

8.  Genetic association of urokinase-type plasminogen activator gene rs2227564 site polymorphism with sporadic Alzheimer's disease in the Han Chinese population.

Authors:  Xuelian Ji; Longfei Jia; Jianping Jia; Li Qi
Journal:  Neural Regen Res       Date:  2012-10-25       Impact factor: 5.135

9.  A Pooled Analysis of Three Randomized Phase I/IIa Clinical Trials Confirms Absence of a Clinically Relevant Effect on the QTc Interval by Umibecestat.

Authors:  Stefan Viktor Vormfelde; Nicole Pezous; Gilbert Lefèvre; Carine Kolly; Ulf Neumann; Pierre Jordaan; Mike Ufer; Eric Legangneux
Journal:  Clin Transl Sci       Date:  2020-07-23       Impact factor: 4.689

10.  Intracellular distribution of amyloid beta peptide and its relationship to the lysosomal system.

Authors:  Lin Zheng; Angel Cedazo-Minguez; Martin Hallbeck; Fredrik Jerhammar; Jan Marcusson; Alexei Terman
Journal:  Transl Neurodegener       Date:  2012-09-26       Impact factor: 8.014
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