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Literature DB >> 16914849

Alzheimer's disease-related alterations in synaptic density: neocortex and hippocampus.

Abstract

Alzheimer's disease (AD) is a progressive disorder that is characterized by the accumulation of neuropathologic lesions and neurochemical alterations. Ultrastructural investigations in many association regions of the neocortex and the hippocampal dentate gyrus have demonstrated a disease-related decline in numerical synaptic density. This decline in brain connectivity occurs early in the disease process and strongly correlates with the cognitive decline observed in AD. The synapse loss does not appear to be an inevitable consequence of the aging process. This article reviews the ultrastructural studies assessing AD-related synaptic loss and the possible compensatory changes in the synaptic complex that occur as a result of the loss in brain connectivity.

Entities: Disease

Mesh：

Year: 2006 PMID： 16914849 DOI： 10.3233/jad-2006-9s312

Source DB: PubMed Journal: J Alzheimers Dis ISSN： 1387-2877 Impact factor: 4.472

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Cited

98 in total

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Authors: Dimitrios Kapogiannis; Mark P Mattson
Journal: Lancet Neurol Date: 2010-12-10 Impact factor: 44.182

Review 2. Actin dynamics and cofilin-actin rods in alzheimer disease.

Authors: James R Bamburg; Barbara W Bernstein
Journal: Cytoskeleton (Hoboken) Date: 2016-03-01

3. PAK inactivation impairs social recognition in 3xTg-AD Mice without increasing brain deposition of tau and Aβ.

Authors: Dany Arsenault; Alexandre Dal-Pan; Cyntia Tremblay; David A Bennett; Matthieu J Guitton; Yves De Koninck; Susumu Tonegawa; Frédéric Calon
Journal: J Neurosci Date: 2013-06-26 Impact factor: 6.167

4. Rostral-Caudal Hippocampal Functional Convergence Is Reduced Across the Alzheimer's Disease Spectrum.

Authors: Joseph Therriault; S Wang; S Mathotaarachchi; Tharick A Pascoal; M Parent; T Beaudry; M Shin; Benedet Al; M S Kang; K P Ng; C Dansereau; M T M Park; V Fonov; F Carbonell; E Zimmer; M Mallar Chakravarty; P Bellec; S Gauthier; P Rosa-Neto
Journal: Mol Neurobiol Date: 2019-06-22 Impact factor: 5.590

Review 5. Implementing neuronal plasticity in NeuroAIDS: the experience of brain-derived neurotrophic factor and other neurotrophic factors.

Authors: Italo Mocchetti; Alessia Bachis; Lee A Campbell; Valeriya Avdoshina
Journal: J Neuroimmune Pharmacol Date: 2013-07-06 Impact factor: 4.147

Review 6. Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies.

Authors: Peter T Nelson; Elizabeth Head; Frederick A Schmitt; Paulina R Davis; Janna H Neltner; Gregory A Jicha; Erin L Abner; Charles D Smith; Linda J Van Eldik; Richard J Kryscio; Stephen W Scheff
Journal: Acta Neuropathol Date: 2011-04-24 Impact factor: 17.088

7. Apolipoprotein E4 (APOE4) Genotype Is Associated with Altered Levels of Glutamate Signaling Proteins and Synaptic Coexpression Networks in the Prefrontal Cortex in Mild to Moderate Alzheimer Disease.

Authors: Robert A Sweet; Matthew L MacDonald; Caitlin M Kirkwood; Ying Ding; Tadhg Schempf; Jackie Jones-Laughner; Julia Kofler; Milos D Ikonomovic; Oscar L Lopez; Megan E Garver; Nicholas F Fitz; Radosveta Koldamova; Nathan A Yates
Journal: Mol Cell Proteomics Date: 2016-04-21 Impact factor: 5.911

Alzheimer's disease-related alterations in synaptic density: neocortex and hippocampus.

Review 1. Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease.

Review 2. Actin dynamics and cofilin-actin rods in alzheimer disease.

3. PAK inactivation impairs social recognition in 3xTg-AD Mice without increasing brain deposition of tau and Aβ.

4. Rostral-Caudal Hippocampal Functional Convergence Is Reduced Across the Alzheimer's Disease Spectrum.

Review 5. Implementing neuronal plasticity in NeuroAIDS: the experience of brain-derived neurotrophic factor and other neurotrophic factors.

Review 6. Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies.

7. Apolipoprotein E4 (APOE4) Genotype Is Associated with Altered Levels of Glutamate Signaling Proteins and Synaptic Coexpression Networks in the Prefrontal Cortex in Mild to Moderate Alzheimer Disease.

8. Pin1 mediates Aβ₄₂-induced dendritic spine loss.

Review 9. Insulin receptor signaling in the development of neuronal structure and function.

Review 10. The role of microglia in synaptic stripping and synaptic degeneration: a revised perspective.

Alzheimer's disease-related alterations in synaptic density: neocortex and hippocampus.

Review 1. Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease.

Review 2. Actin dynamics and cofilin-actin rods in alzheimer disease.

3. PAK inactivation impairs social recognition in 3xTg-AD Mice without increasing brain deposition of tau and Aβ.

4. Rostral-Caudal Hippocampal Functional Convergence Is Reduced Across the Alzheimer's Disease Spectrum.

Review 5. Implementing neuronal plasticity in NeuroAIDS: the experience of brain-derived neurotrophic factor and other neurotrophic factors.

Review 6. Alzheimer's disease is not "brain aging": neuropathological, genetic, and epidemiological human studies.

7. Apolipoprotein E*4 (APOE*4) Genotype Is Associated with Altered Levels of Glutamate Signaling Proteins and Synaptic Coexpression Networks in the Prefrontal Cortex in Mild to Moderate Alzheimer Disease.

8. Pin1 mediates Aβ42-induced dendritic spine loss.

Review 9. Insulin receptor signaling in the development of neuronal structure and function.

Review 10. The role of microglia in synaptic stripping and synaptic degeneration: a revised perspective.

7. Apolipoprotein E4 (APOE4) Genotype Is Associated with Altered Levels of Glutamate Signaling Proteins and Synaptic Coexpression Networks in the Prefrontal Cortex in Mild to Moderate Alzheimer Disease.

8. Pin1 mediates Aβ₄₂-induced dendritic spine loss.