Literature DB >> 16914848

Synaptic remodeling during aging and in Alzheimer's disease.

Eliezer Masliah1, Leslie Crews, Lawrence Hansen.   

Abstract

Cognitive functioning is dependent on synapse density in the brain. Factors modulating synapse density might include the balance between synaptic pruning and sprouting. Loss of synapses during aging might explain cognitive decline and while previous reports have suggested a 10-15% synapse loss occurs during the normal aging process, more recent studies have found that decline in synaptic density only occurs after 65 years of age. In this context, the main objective of this manuscript is to discuss the findings of our 1993 study in light of more recent studies in aging, synapses and Alzheimer's disease.

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Year:  2006        PMID： 16914848     DOI： 10.3233/jad-2006-9s311

Source DB:  PubMed          Journal:  J Alzheimers Dis        ISSN： 1387-2877            Impact factor:   4.472


  49 in total

1.  Entorhinal verrucae geometry is coincident and correlates with Alzheimer's lesions: a combined neuropathology and high-resolution ex vivo MRI analysis.

Authors:  Jean C Augustinack; Kristen E Huber; Gheorghe M Postelnicu; Sita Kakunoori; Ruopeng Wang; André J W van der Kouwe; Lawrence L Wald; Thor D Stein; Matthew P Frosch; Bruce Fischl
Journal:  Acta Neuropathol       Date:  2011-12-13       Impact factor: 17.088

2.  PAK inactivation impairs social recognition in 3xTg-AD Mice without increasing brain deposition of tau and Aβ.

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Journal:  J Neurosci       Date:  2013-06-26       Impact factor: 6.167

3.  An engulfment assay: a protocol to assess interactions between CNS phagocytes and neurons.

Authors:  Dorothy P Schafer; Emily K Lehrman; Christopher T Heller; Beth Stevens
Journal:  J Vis Exp       Date:  2014-06-08       Impact factor: 1.355

Review 4.  Intraneuronal beta-amyloid accumulation and synapse pathology in Alzheimer's disease.

Authors:  Gunnar K Gouras; Davide Tampellini; Reisuke H Takahashi; Estibaliz Capetillo-Zarate
Journal:  Acta Neuropathol       Date:  2010-03-31       Impact factor: 17.088

Review 5.  Disordered APP metabolism and neurovasculature in trauma and aging: Combined risks for chronic neurodegenerative disorders.

Authors:  Milos D Ikonomovic; Zhiping Mi; Eric E Abrahamson
Journal:  Ageing Res Rev       Date:  2016-11-06       Impact factor: 10.895

6.  Synaptic protein deficits are associated with dementia irrespective of extreme old age.

Authors:  Michal Schnaider Beeri; Vahram Haroutunian; James Schmeidler; Mary Sano; Peter Fam; Aaron Kavanaugh; Alasdair M Barr; William G Honer; Pavel Katsel
Journal:  Neurobiol Aging       Date:  2011-12-27       Impact factor: 4.673

7.  Difference in muscle quality over the adult life span and biological correlates in the Baltimore Longitudinal Study of Aging.

Authors:  Ann Zenobia Moore; Giorgio Caturegli; E Jeffrey Metter; Sokratis Makrogiannis; Susan M Resnick; Tamara B Harris; Luigi Ferrucci
Journal:  J Am Geriatr Soc       Date:  2014-01-17       Impact factor: 5.562

8.  Caspase-3 is enriched in postsynaptic densities and increased in Alzheimer's disease.

Authors:  Natalia Louneva; Julia W Cohen; Li-Ying Han; Konrad Talbot; Robert S Wilson; David A Bennett; John Q Trojanowski; Steven E Arnold
Journal:  Am J Pathol       Date:  2008-09-25       Impact factor: 4.307

Review 9.  Insulin receptor signaling in the development of neuronal structure and function.

Authors:  Shu-Ling Chiu; Hollis T Cline
Journal:  Neural Dev       Date:  2010-03-15       Impact factor: 3.842

10.  Neuronal and cognitive plasticity: a neurocognitive framework for ameliorating cognitive aging.

Authors:  Pamela M Greenwood; Raja Parasuraman
Journal:  Front Aging Neurosci       Date:  2010-11-29       Impact factor: 5.750
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