PURPOSE: To evaluate the effectiveness of autologous fibrin tissue adhesive (auto-FTA) in reducing blood loss during cementless total hip arthroplasty (THA). METHODS:From September 2000 to August 2001, 100 patients who predonated 400 ml of autologous blood were randomised to undergo either standard treatment with auto-FTA (auto-FTA group) or standard treatment alone (control group). The volume of postoperative blood loss and the decrease in haemoglobin level were measured. All patients were followed up for 3 years to evaluate the rate of bone ingrowth and heterotopic ossification. RESULTS: The mean postoperative blood loss was 580 ml (standard deviation [SD], 240 ml) in the auto-FTA group and 810 ml (SD, 341 ml) in the control group; the difference was significant (230 ml, p<0.001). The decrease in haemoglobin concentration was 17 g/l (SD, 11 g/l) in the auto-FTA group and 22 g/l (SD, 12 g/l) in the control group. The difference was significant (5 g/l, p=0.03). The percentage of total blood loss of >1200 ml in any single patient was significantly lower in the auto-FTA group (4%) than in the control group (20%) [p=0.01]. CONCLUSION:Auto-FTA is a safe and effective means of reducing perioperative blood loss in THA.
RCT Entities:
PURPOSE: To evaluate the effectiveness of autologous fibrin tissue adhesive (auto-FTA) in reducing blood loss during cementless total hip arthroplasty (THA). METHODS: From September 2000 to August 2001, 100 patients who predonated 400 ml of autologous blood were randomised to undergo either standard treatment with auto-FTA (auto-FTA group) or standard treatment alone (control group). The volume of postoperative blood loss and the decrease in haemoglobin level were measured. All patients were followed up for 3 years to evaluate the rate of bone ingrowth and heterotopic ossification. RESULTS: The mean postoperative blood loss was 580 ml (standard deviation [SD], 240 ml) in the auto-FTA group and 810 ml (SD, 341 ml) in the control group; the difference was significant (230 ml, p<0.001). The decrease in haemoglobin concentration was 17 g/l (SD, 11 g/l) in the auto-FTA group and 22 g/l (SD, 12 g/l) in the control group. The difference was significant (5 g/l, p=0.03). The percentage of total blood loss of >1200 ml in any single patient was significantly lower in the auto-FTA group (4%) than in the control group (20%) [p=0.01]. CONCLUSION: Auto-FTA is a safe and effective means of reducing perioperative blood loss in THA.
Authors: Jason D Wright; Cande V Ananth; Sharyn N Lewin; William M Burke; Zainab Siddiq; Alfred I Neugut; Thomas J Herzog; Dawn L Hershman Journal: J Surg Res Date: 2013-08-13 Impact factor: 2.192
Authors: David M Joyce; Alison K Klika; Amar Mutnal; Viktor Krebs; Robert Molloy; Ulf Knothe; Wael K Barsoum Journal: Blood Transfus Date: 2015-04-21 Impact factor: 3.443
Authors: Antonio Ziranu; Cesare Meschini; Davide De Marco; Giuseppe Sircana; Maria Serena Oliva; Giusepp Rovere; Andrea Corbingi; Raffaele Vitiello; Giulio Maccauro; Enrico Pola Journal: Orthop Rev (Pavia) Date: 2022-10-13
Authors: Lorenzo A Orci; Graziano Oldani; Thierry Berney; Axel Andres; Gilles Mentha; Philippe Morel; Christian Toso Journal: HPB (Oxford) Date: 2013-03-06 Impact factor: 3.647
Authors: Jamie S McConnell; Sandeep Shewale; Niall A Munro; Kalpesh Shah; Angela H Deakin; Andrew W G Kinninmonth Journal: Acta Orthop Date: 2011-10-17 Impact factor: 3.717