Literature DB >> 16914695

Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients.

J M Leung1, L P Sands, M Rico, K L Petersen, M C Rowbotham, J B Dahl, C Ames, D Chou, P Weinstein.   

Abstract

In this randomized pilot clinical trial, the authors tested the hypothesis that using gabapentin as an add-on agent in the treatment of postoperative pain reduces the occurrence of postoperative delirium. Postoperative delirium occurred in 5/12 patients (42%) who received placebo vs 0/9 patients who received gabapentin, p = 0.045. The reduction in delirium appears to be secondary to the opioid-sparing effect of gabapentin.

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Year:  2006        PMID： 16914695     DOI： 10.1212/01.wnl.0000233831.87781.a9

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  36 in total

1.  Postoperative delirium: a 76-year-old woman with delirium following surgery.

Authors:  Edward R Marcantonio
Journal:  JAMA       Date:  2012-07-04       Impact factor: 56.272

Review 2.  Delirium in hospitalized patients: implications of current evidence on clinical practice and future avenues for research--a systematic evidence review.

Authors:  Babar A Khan; Mohammed Zawahiri; Noll L Campbell; George C Fox; Eric J Weinstein; Arif Nazir; Mark O Farber; John D Buckley; Alasdair Maclullich; Malaz A Boustani
Journal:  J Hosp Med       Date:  2012-06-08       Impact factor: 2.960

3.  Update on Pharmacotherapy for Prevention and Treatment of Post-operative Delirium: A Systematic Evidence Review.

Authors:  Babar A Khan; Daniel Gutteridge; Noll L Campbell
Journal:  Curr Anesthesiol Rep       Date:  2015-03

Review 4.  Delirium in older adults.

Authors:  Dennis M Popeo
Journal:  Mt Sinai J Med       Date:  2011 Jul-Aug

5.  Does preoperative risk for delirium moderate the effects of postoperative pain and opiate use on postoperative delirium?

Authors:  Jacqueline M Leung; Laura P Sands; Eunjung Lim; Tiffany L Tsai; Sakura Kinjo
Journal:  Am J Geriatr Psychiatry       Date:  2013-05-06       Impact factor: 4.105

6.  Management of cognition as reported in Japanese historical documents and modern anesthesiology research papers.

Authors:  Shigeru Saito
Journal:  J Anesth       Date:  2016-07-20       Impact factor: 2.078

Review 7.  Pharmacologic prevention of postoperative delirium.

Authors:  M Gosch; J A Nicholas
Journal:  Z Gerontol Geriatr       Date:  2014-02       Impact factor: 1.281

8.  Perioperative Gabapentin Does Not Reduce Postoperative Delirium in Older Surgical Patients: A Randomized Clinical Trial.

Authors:  Jacqueline M Leung; Laura P Sands; Ningning Chen; Christopher Ames; Sigurd Berven; Kevin Bozic; Shane Burch; Dean Chou; Kenneth Covinsky; Vedat Deviren; Sakura Kinjo; Joel H Kramer; Michael Ries; Bobby Tay; Thomas Vail; Philip Weinstein; Stacey Chang; Gabriela Meckler; Stacey Newman; Tiffany Tsai; Vanessa Voss; Emily Youngblom
Journal:  Anesthesiology       Date:  2017-10       Impact factor: 7.892

Review 9.  Delirium in patients with cancer: assessment, impact, mechanisms and management.

Authors:  Peter G Lawlor; Shirley H Bush
Journal:  Nat Rev Clin Oncol       Date:  2014-09-02       Impact factor: 66.675

Review 10.  Pharmacological management of delirium in hospitalized adults--a systematic evidence review.

Authors:  Noll Campbell; Malaz A Boustani; Amir Ayub; George C Fox; Stephanie L Munger; Carol Ott; Oscar Guzman; Mark Farber; Adetayo Ademuyiwa; Ranjeet Singh
Journal:  J Gen Intern Med       Date:  2009-05-08       Impact factor: 5.128
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