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Literature DB >> 16914639

Is active psychosis neurotoxic?

T H McGlashan¹.
1. thomas.mcglashan@yale.edu

Abstract

Positive symptoms of psychosis disrupt mentation. Do they also engineer brain cell death and deterioration? This hypothesis is currently popular as an explanation of the duration of untreated psychosis effect in early schizophrenia. The clinical and neurobiological evidence for its validity is visited and found wanting. Synaptic plasticity, not neurotoxicity, appears to be the mediating process.

Entities: Disease

Mesh：

Substances：
Antipsychotic Agents

Year: 2006 PMID： 16914639 PMCID： PMC2632265 DOI： 10.1093/schbul/sbl032

Source DB: PubMed Journal: Schizophr Bull ISSN： 0586-7614 Impact factor: 9.306

32 in total

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Journal: Schizophr Bull Date: 1988 Impact factor: 9.306

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Journal: Arch Gen Psychiatry Date: 1993-05

6. Subtype progression and pathophysiologic deterioration in early schizophrenia.

Authors: T H McGlashan; W S Fenton
Journal: Schizophr Bull Date: 1993 Impact factor: 9.306

Review 7. Parallel distributed processing and the emergence of schizophrenic symptoms.

Authors: R E Hoffman; T H McGlashan
Journal: Schizophr Bull Date: 1993 Impact factor: 9.306

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Authors: B Pakkenberg
Journal: Br J Psychiatry Date: 1987-12 Impact factor: 9.319

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Authors: A D Loebel; J A Lieberman; J M Alvir; D I Mayerhoff; S H Geisler; S R Szymanski
Journal: Am J Psychiatry Date: 1992-09 Impact factor: 18.112

25 in total

1. Neurocognition in schizophrenia: a 20-year multi-follow-up of the course of processing speed and stored knowledge.

Authors: Aaron Bonner-Jackson; Linda S Grossman; Martin Harrow; Cherise Rosen
Journal: Compr Psychiatry Date: 2010-03-29 Impact factor: 3.735

2. Glutamate as a marker of cognitive function in schizophrenia: a proton spectroscopic imaging study at 4 Tesla.

Authors: Juan R Bustillo; Hongji Chen; Charles Gasparovic; Paul Mullins; Arvind Caprihan; Clifford Qualls; William Apfeldorf; John Lauriello; Stefan Posse
Journal: Biol Psychiatry Date: 2010-10-20 Impact factor: 13.382

Review 3. Family functioning in first-episode psychosis: a systematic review of the literature.

Authors: Katerina Koutra; Alexandros N Vgontzas; Christos Lionis; Sofia Triliva
Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2014-01-10 Impact factor: 4.328

Review 4. Are the effects of duration of untreated psychosis socially mediated?

Authors: Ross M G Norman
Journal: Can J Psychiatry Date: 2014-10 Impact factor: 4.356

Review 5. The role of untreated psychosis in neurodegeneration: a review of hypothesized mechanisms of neurotoxicity in first-episode psychosis.

Authors: Kelly K Anderson; Aristotle Voineskos; Benoit H Mulsant; Tony P George; Kwame J Mckenzie
Journal: Can J Psychiatry Date: 2014-10 Impact factor: 4.356

6. Gender effects on brain changes in early-onset psychosis.

Authors: Marta Rapado-Castro; Cali F Bartholomeusz; Josefina Castro-Fornieles; Ana González-Pinto; Soraya Otero; Inmaculada Baeza; Carmen Moreno; Montserrat Graell; Joost Janssen; Nuria Bargalló; Christos Pantelis; Manuel Desco; Celso Arango
Journal: Eur Child Adolesc Psychiatry Date: 2015-01-15 Impact factor: 4.785

7. The impact of psychosis on the course of cognition: a prospective, nested case-control study in individuals at clinical high-risk for psychosis.

Authors: R E Carrión; D McLaughlin; A M Auther; R Olsen; C U Correll; B A Cornblatt
Journal: Psychol Med Date: 2015-07-14 Impact factor: 7.723