BACKGROUND: Thyroid hormones are necessary for normal brain development. We studied thyroid hormone profile and insulin sensitivity in intrauterine growth retarded (IUGR) newborns to find correlation between insulin sensitivity and thyroid status in IUGR newborns. METHODS: Fifty IUGR and fifty healthy control infants were studied at birth. Cord blood was collected for determination of T(3), T(4), TSH, glucose and insulin levels. RESULTS: IUGR newborns had significantly lower insulin, mean+/-S.D., 5.25+/-2.81 vs. 11.02+/-1.85microU/ml, but significantly higher insulin sensitivity measured as glucose to insulin ratio (G/I), 9.80+/-2.91 vs. 6.93+/-1.08 compared to healthy newborns. TSH was also significantly higher 6.0+/-2.70 vs. 2.99+/-1.05microU/ml with significantly lower T(4), 8.65+/-1.95 vs. 9.77+/-2.18microg/dl, but similar T(3) levels, 100.8+/-24.36 vs. 101.45+/-23.45ng/dl. On stepwise linear regression analysis in IUGR infants, insulin sensitivity was found to have a significant negative association with T(4) and significant positive association with TSH. CONCLUSION: Thyroid hormones may play a role in increased insulin sensitivity at birth in IUGR.
BACKGROUND: Thyroid hormones are necessary for normal brain development. We studied thyroid hormone profile and insulin sensitivity in intrauterine growth retarded (IUGR) newborns to find correlation between insulin sensitivity and thyroid status in IUGR newborns. METHODS: Fifty IUGR and fifty healthy control infants were studied at birth. Cord blood was collected for determination of T(3), T(4), TSH, glucose and insulin levels. RESULTS: IUGR newborns had significantly lower insulin, mean+/-S.D., 5.25+/-2.81 vs. 11.02+/-1.85microU/ml, but significantly higher insulin sensitivity measured as glucose to insulin ratio (G/I), 9.80+/-2.91 vs. 6.93+/-1.08 compared to healthy newborns. TSH was also significantly higher 6.0+/-2.70 vs. 2.99+/-1.05microU/ml with significantly lower T(4), 8.65+/-1.95 vs. 9.77+/-2.18microg/dl, but similar T(3) levels, 100.8+/-24.36 vs. 101.45+/-23.45ng/dl. On stepwise linear regression analysis in IUGR infants, insulin sensitivity was found to have a significant negative association with T(4) and significant positive association with TSH. CONCLUSION: Thyroid hormones may play a role in increased insulin sensitivity at birth in IUGR.
Authors: James S Barry; Paul J Rozance; Laura D Brown; Russell V Anthony; Kent L Thornburg; William W Hay Journal: Exp Biol Med (Maywood) Date: 2016-02-11
Authors: Renata de Azevedo Melo Luvizotto; André Ferreira do Nascimento; Maria Teresa de Síbio; Regiane Marques Castro Olímpio; Sandro José Conde; Ana Paula Lima-Leopoldo; André Soares Leopoldo; Antonio Carlos Cicogna; Célia Regina Nogueira Journal: ScientificWorldJournal Date: 2012-05-03
Authors: Laura Lucaccioni; Monica Ficara; Valentina Cenciarelli; Alberto Berardi; Barbara Predieri; Lorenzo Iughetti Journal: Acta Biomed Date: 2020-09-15
Authors: Maria Teresa De Sibio; Renata Azevedo Melo Luvizotto; Regiane Marques Castro Olimpio; Camila Renata Corrêa; Juliana Marino; Miriane de Oliveira; Sandro José Conde; Ana Lúcia dos Anjos Ferreira; Carlos Roberto Padovani; Célia Regina Nogueira Journal: PLoS One Date: 2013-02-28 Impact factor: 3.240