BACKGROUND: The exact time-course of N-terminal pro-brain natriuretic peptide (NT-proBNP) and the prognostic importance in the immediate phase of ischemic stroke have not been established. METHODS: NT-proBNP was measured daily from admission to day 5 and again at 6-month follow-up in 250 consecutive patients with acute ischemic stroke. RESULTS: NT-proBNP peaked the day after onset of symptoms (p = 0.007) followed by a decrease until day 5 (p = 0.001, ANOVA). At 6-month follow-up the difference in the level of NT-proBNP was unchanged compared to day 5 (p = 0.42). NT-proBNP levels > or =615 pg/ml at day 2 after onset of symptoms was associated with 6-month mortality. CONCLUSION: NT-proBNP peaks the day after onset of symptoms in patients with acute ischemic stroke. A single measurement of NT-proBNP appears to be an indicator of 6-month mortality. Copyright (c) 2006 S. Karger AG, Basel.
BACKGROUND: The exact time-course of N-terminal pro-brain natriuretic peptide (NT-proBNP) and the prognostic importance in the immediate phase of ischemic stroke have not been established. METHODS: NT-proBNP was measured daily from admission to day 5 and again at 6-month follow-up in 250 consecutive patients with acute ischemic stroke. RESULTS: NT-proBNP peaked the day after onset of symptoms (p = 0.007) followed by a decrease until day 5 (p = 0.001, ANOVA). At 6-month follow-up the difference in the level of NT-proBNP was unchanged compared to day 5 (p = 0.42). NT-proBNP levels > or =615 pg/ml at day 2 after onset of symptoms was associated with 6-month mortality. CONCLUSION: NT-proBNP peaks the day after onset of symptoms in patients with acute ischemic stroke. A single measurement of NT-proBNP appears to be an indicator of 6-month mortality. Copyright (c) 2006 S. Karger AG, Basel.
Authors: W T Longstreth; Richard A Kronmal; John L P Thompson; Robert H Christenson; Steven R Levine; Rebecca Gross; Robin L Brey; Richard Buchsbaum; Mitchell S V Elkind; David L Tirschwell; Stephen L Seliger; J P Mohr; Christopher R deFilippi Journal: Stroke Date: 2013-01-22 Impact factor: 7.914
Authors: Peter U Heuschmann; Felipe A Montellano; Kathrin Ungethüm; Viktoria Rücker; Silke Wiedmann; Daniel Mackenrodt; Anika Quilitzsch; Timo Ludwig; Peter Kraft; Judith Albert; Caroline Morbach; Stefan Frantz; Stefan Störk; Karl Georg Haeusler; Christoph Kleinschnitz Journal: ESC Heart Fail Date: 2020-12-22