Literature DB >> 16912328

Integration site choice of a feline immunodeficiency virus vector.

Yubin Kang1, Christopher J Moressi, Todd E Scheetz, Litao Xie, Diane Thi Tran, Thomas L Casavant, Prashanth Ak, Craig J Benham, Beverly L Davidson, Paul B McCray.   

Abstract

We mapped 226 unique integration sites in human hepatoma cells following gene transfer with a feline immunodeficiency virus (FIV)-based lentivirus vector. FIV integrated across the entire length of the transcriptional units. Microarray data indicated that FIV integration favored actively transcribed genes. Approximately 21% of FIV integrations within transcriptional units occurred in genes regulated by the LEDGF/p75 transcriptional coactivator. DNA in regions of FIV insertion sites exhibited a "bendable" structure and a pattern of duplex destabilization favoring strand separation. FIV integration preferences are more similar to those of primate lentiviruses and distinct from those of Moloney murine leukemia virus, avian sarcoma leukosis virus, and foamy virus.

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Year:  2006        PMID： 16912328      PMCID： PMC1563849          DOI： 10.1128/JVI.00719-06

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  27 in total

1.  HIV-1 integration in the human genome favors active genes and local hotspots.

Authors:  Astrid R W Schröder; Paul Shinn; Huaming Chen; Charles Berry; Joseph R Ecker; Frederic Bushman
Journal:  Cell       Date:  2002-08-23       Impact factor: 41.582

2.  In vivo treatment of hemophilia A and mucopolysaccharidosis type VII using nonprimate lentiviral vectors.

Authors:  C S Stein; Y Kang; S L Sauter; K Townsend; P Staber; T A Derksen; I Martins; J Qian; B L Davidson; P B McCray
Journal:  Mol Ther       Date:  2001-06       Impact factor: 11.454

3.  Feline immunodeficiency virus vectors persistently transduce nondividing airway epithelia and correct the cystic fibrosis defect.

Authors:  G Wang; V Slepushkin; J Zabner; S Keshavjee; J C Johnston; S L Sauter; D J Jolly; T W Dubensky; B L Davidson; P B McCray
Journal:  J Clin Invest       Date:  1999-12       Impact factor: 14.808

4.  Common physical properties of DNA affecting target site selection of sleeping beauty and other Tc1/mariner transposable elements.

Authors:  Thomas J Vigdal; Christopher D Kaufman; Zsuzsanna Izsvák; Daniel F Voytas; Zoltán Ivics
Journal:  J Mol Biol       Date:  2002-10-25       Impact factor: 5.469

5.  Viral-mediated gene transfer to mouse primary neural progenitor cells.

Authors:  Stephanie M Hughes; Farid Moussavi-Harami; Sybille L Sauter; Beverly L Davidson
Journal:  Mol Ther       Date:  2002-01       Impact factor: 11.454

6.  Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors.

Authors:  Andrew I Brooks; Colleen S Stein; Stephanie M Hughes; Jason Heth; Paul M McCray; Sybille L Sauter; Julie C Johnston; Deborah A Cory-Slechta; Howard J Federoff; Beverly L Davidson
Journal:  Proc Natl Acad Sci U S A       Date:  2002-04-16       Impact factor: 11.205

7.  Efficient transduction of nondividing human cells by feline immunodeficiency virus lentiviral vectors.

Authors:  E M Poeschla; F Wong-Staal; D J Looney
Journal:  Nat Med       Date:  1998-03       Impact factor: 53.440

8.  The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding.

Authors:  Katrien Busschots; Jo Vercammen; Stéphane Emiliani; Richard Benarous; Yves Engelborghs; Frauke Christ; Zeger Debyser
Journal:  J Biol Chem       Date:  2005-03-04       Impact factor: 5.157

9.  LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes.

Authors:  Manuel Llano; Maria Vanegas; Oliver Fregoso; Dyana Saenz; Susan Chung; Mary Peretz; Eric M Poeschla
Journal:  J Virol       Date:  2004-09       Impact factor: 5.103

10.  Transcription start regions in the human genome are favored targets for MLV integration.

Authors:  Xiaolin Wu; Yuan Li; Bruce Crise; Shawn M Burgess
Journal:  Science       Date:  2003-06-13       Impact factor: 47.728
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  25 in total

Review 1.  Immunization delivered by lentiviral vectors for cancer and infectious diseases.

Authors:  Biliang Hu; April Tai; Pin Wang
Journal:  Immunol Rev       Date:  2011-01       Impact factor: 12.988

2.  HIV integration site selection: analysis by massively parallel pyrosequencing reveals association with epigenetic modifications.

Authors:  Gary P Wang; Angela Ciuffi; Jeremy Leipzig; Charles C Berry; Frederic D Bushman
Journal:  Genome Res       Date:  2007-06-01       Impact factor: 9.043

Review 3.  Integrase, LEDGF/p75 and HIV replication.

Authors:  E M Poeschla
Journal:  Cell Mol Life Sci       Date:  2008-05       Impact factor: 9.261

Review 4.  Integration site selection by retroviral vectors: molecular mechanism and clinical consequences.

Authors:  René Daniel; Johanna A Smith
Journal:  Hum Gene Ther       Date:  2008-06       Impact factor: 5.695

Review 5.  Chromatin tethering and retroviral integration: recent discoveries and parallels with DNA viruses.

Authors:  Anne M Meehan; Eric M Poeschla
Journal:  Biochim Biophys Acta       Date:  2009-10-15

Review 6.  Human gene therapy vectors derived from feline lentiviruses.

Authors:  Román A Barraza; Eric M Poeschla
Journal:  Vet Immunol Immunopathol       Date:  2008-01-19       Impact factor: 2.046

7.  Lentiviral integration preferences in transgenic mice.

Authors:  Shang-Hsun Yang; Pei-Hsun Cheng; Robert T Sullivan; James W Thomas; Anthony W S Chan
Journal:  Genesis       Date:  2008-12       Impact factor: 2.487

8.  Fidelity of target site duplication and sequence preference during integration of xenotropic murine leukemia virus-related virus.

Authors:  Sanggu Kim; Alice Rusmevichientong; Beihua Dong; Roland Remenyi; Robert H Silverman; Samson A Chow
Journal:  PLoS One       Date:  2010-04-20       Impact factor: 3.240

9.  Integration site preference of xenotropic murine leukemia virus-related virus, a new human retrovirus associated with prostate cancer.

Authors:  Sanggu Kim; Namshin Kim; Beihua Dong; David Boren; Serena A Lee; Jaydip Das Gupta; Christina Gaughan; Eric A Klein; Christopher Lee; Robert H Silverman; Samson A Chow
Journal:  J Virol       Date:  2008-08-06       Impact factor: 5.103

10.  Functional and structural characterization of the integrase from the prototype foamy virus.

Authors:  Eugene Valkov; Saumya Shree Gupta; Stephen Hare; Anna Helander; Pietro Roversi; Myra McClure; Peter Cherepanov
Journal:  Nucleic Acids Res       Date:  2008-11-26       Impact factor: 16.971
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